SBIR Phase I: Selective Laser Sintering of Bioglass Scaffolds for Bone Tissue Engineering

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。这个由Mo-Sci公司提交的小企业创新研究（SBIR）一期项目提出开发一种新型的人工合成骨组织支架，通过选择性激光烧结（SLS）制造，以模仿正常健康的小梁骨组织的结构和力学性能，并尽可能快地促进血管化。这种创新的组织工程技术既可用于体外骨组织生长，也可作为直接植入的人工合成骨移植材料。利用生物活性玻璃颗粒作为原料，SLS独特的3D制造能力将被用来制造可吸收的组织支架，模仿小梁骨的结构和机械性能。这项研究的更广泛的影响是为由于人口老龄化而面临越来越多的骨病和骨折负担的人们提供合成骨材料。提出的新型骨组织支架将推动骨组织体外生长的进展。这些骨组织支架也可以直接用作合成骨移植物，以满足未来十年越来越多的个体因骨病和骨折而需要恢复骨骼结构和功能的需求。Mo-Sci公司和密苏里科技大学（Missouri University of Science & Technology）之间的合作将促进SLS制造领域的工业合作伙伴和学术界之间的紧密联系。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Small Business Innovation Research (SBIR) Phase I project submitted by Mo-Sci Corp. proposes to develop a novel synthetic bone tissue scaffold manufactured by selective laser sintering (SLS) to mimic the structure and mechanical properties of normal healthy trabecular bone tissue, and with high vascularization promotion as quickly as possible. This innovative tissue engineering technology could be applied to in vitro bone tissue growth as well as a synthetic graft material for direct implantation. Using bioactive glass particles as feedstock, the unique 3D fabrication capabilities of SLS will be utilized to generate resorbable tissue scaffolds that mimic the structure and mechanical properties of trabecular bone.The broader impacts of this research are to provide synthetic bone materials for people who are facing a growing burden from bone disease and fracture due to the aging of the population. The novel bone tissue scaffolds proposed will enable progress in the in vitro growth of bone tissue. These bone tissue scaffolds can also be used directly as synthetic bone grafts in order to meet the needs of the increasing number of individuals who will require restoration of skeletal structure and function due to bone disease and fracture in the next decade. The collaboration between Mo-Sci Corp. and the Missouri University of Science & Technology (Missouri S&T) will promote a strong link between an industrial partner and academia in SLS manufacturing.