COLLABORATIVE RESEARCH: Estimating Species Trees with Population Genetic Approaches: Working Towards a New Phylogenetic Paradigm for 21st Century Phylogenetics

该奖项是根据2009年美国复苏和再投资法案(公法111-5)资助的。研究生物多样性的一个基本问题是理解物种之间的关系。这是通过开发树来描述它们的关系并促进它们的研究来实现的，这是系统发育学领域的研究。当这种树是从DNA序列发育而来的时候，它们不一定与从形态发育的树匹配，甚至不一定与从其他DNA序列发育的树匹配。从DNA发展树木的理论没有考虑种群遗传学，也没有考虑真实数据的杂乱无章(例如，有限的遗传变异、缺失的数据、无法对树木中的所有物种进行采样，以及现实的采样工作)。这项得到资助的工作将通过理论开发，然后用计算机模拟和从众所周知的研究物种收集的数据进行测试，来解决这些问题。研究人员将为准确的树种估计开发软件和指南，确定这些新方法的局限性，并确定未来理论和方法发展的领域。PI将培训博士后和研究生。将通过研讨会和在网上免费提供该软件，向全国学生和教职员工提供在系统发育和种群遗传学方面进行交叉培训的机会。计算机研讨会将在这些方法的理论基础和有兴趣应用它们的人的背景之间架起一座桥梁。因此，鉴于树种在生物学中的核心作用，该项目将为不同领域的研究人员提供工具。该项目开辟了一条新的研究路线，对于研究生物多样性及其变化的基础科学家和应用科学家来说都应该是无价的。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).A fundamental issue in studying biodiversity is understanding the relationship between species. This is approached by developing trees that describe the relationships and facilitate their study, the field of phylogenetics. When such trees are developed from DNA sequences, they do not necessarily match trees developed from morphology, or even trees developed from other DNA sequences. The theory for developing trees from DNA does not take population genetics into consideration, or the messiness of real data (e.g., limited genetic variation, missing data, inability to sample all species in a tree, and realistic sampling effort). The funded work will address these issues though theory development followed by testing with both computer simulations and data collected from well-understood study species. The investigators will develop software and guidelines for accurate species-tree estimation, identify the limits of these new methods, and identify areas for future theoretical and methodological development.The PIs will train postdocs and graduate students. Opportunities for cross-training in phylogenetics and population genetics will be provided to students and faculty nationwide through workshops and making the software freely available on the web. A computer workshop will bridge the gap between the theoretical basis of the methods and the backgrounds of those interested in applying them. Thus the project will provide tools to a diverse cross-section of researchers, given the central role of species trees in biology. This project opens a new line of research that should be invaluable to both basic and applied scientists who study biodiversity and its changes.