RIG: Development of a General Use Phylogenomic Toolkit Using Iguanid Lizards and Phylogenetic Profiling

RIG：使用鬣蜥和系统发育分析开发通用系统发育工具包

• 批准号: 0920318
• 负责人: James Schulte
• 金额: $ 17.5万
• 依托单位: Clarkson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0920318&HistoricalAwards=false
• 关键词: RIG; Development; General; Use; Phylogenomic

Rapid availability of genomic data from many species has significantly increased the amount of data systematists can use to accurately recover the Tree of Life for all species. However, some data classes are more informative than others for recovering accurate results. This project will explore different classes of DNA data from the nuclear genome and quantify the ability of these classes to recover different branches in two exemplar lizard groups. Genetic information profiles, which identify optimal time points when genes are most informative for phylogenetic analysis, will be generated for each group. This research will generate a genomic toolkit that will be of wide utility for all vertebrate systematists and that will enable them to identify genes that are most informative for the Tree of Life region on which they are working. As part of this project, undergraduate students will receive extensive training in fields such as systematics, bioinformatics, database mining, lab techniques, and statistical analysis, and will be given opportunities to attend local and national scientific meetings. The PI and his undergraduates will conduct a week-long summer workshop on Northern New York Biodiversity for high school students from the Akwesasne St. Regis Mohawk Reservation to promote greater interest in science among Native American students in the region.

来自许多物种的基因组数据的快速可用性显着增加了系统学家可以用来准确恢复所有物种生命之树的数据量。然而，对于恢复准确的结果，某些数据类比其他数据类提供更多信息。该项目将探索核基因组中不同类别的 DNA 数据，并量化这些类别在两个典型蜥蜴类群中恢复不同分支的能力。将为每个组生成遗传信息图谱，该图谱确定基因对系统发育分析最有信息的最佳时间点。这项研究将产生一个基因组工具包，该工具包对所有脊椎动物系统学家都有广泛的用途，并使他们能够识别出对他们正在研究的生命之树区域信息最丰富的基因。作为该项目的一部分，本科生将接受系统学、生物信息学、数据库挖掘、实验室技术和统计分析等领域的广泛培训，并将有机会参加地方和国家科学会议。 PI 和他的本科生将为 Akwesasne St. Regis Mohawk 保留地的高中生举办为期一周的纽约北部生物多样性夏季研讨会，以提高该地区美国原住民学生对科学的兴趣。