Loss and rescue of regeneration in naidine annelids

环节动物再生能力的丧失与挽救

基本信息

  • 批准号:
    0920502
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). Animals vary tremendously in their ability to replace lost body parts. While some animals, such as humans, cannot re-grow most body parts, others, such as some segmented worms, can re-grow an entire body from a small fragment of the original animal. The ultimate goal of this research is to understand the root causes of this variation and to identify factors that can cause regeneration, the process of body part replacement, to fail or proceed. Specifically, this work focuses on two closely related species of segmented worms, one that can regenerate its head and the other that cannot do so except when the cut occurs within developmentally very young tissue. Investigations in these two species will identify genes and developmental processes that may allow an animal to regenerate even when it usually cannot do so. Determining the specific conditions under which regeneration can be elicited in an otherwise non-regenerating species will further understanding of the natural blocks to successful regeneration and suggest paths to circumventing these blocks. This work will foster the training of a diverse group of undergraduate, graduate, and post-graduate researchers within an environment highly supportive of strong mentoring. This laboratory has provided and will continue to provide opportunities to diverse students including underrepresented groups such as minorities. Lab personnel will actively participate in disseminating research results, and research findings will be disseminated broadly and in a timely manner. Genetic resources will be made available to the research community through a freely available sequence repository shortly after acquisition.
该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。动物在替换失去的身体部位的能力上存在巨大差异。虽然有些动物,如人类,不能重新生长大部分身体部位,但另一些动物,如一些节段性蠕虫,可以从原始动物的一小部分重新生长整个身体。这项研究的最终目标是了解这种变异的根本原因,并确定可能导致再生的因素,即身体部分替换的过程,失败或继续。具体地说,这项工作集中在两种密切相关的节段性蠕虫上,一种可以再生头部,另一种不能再生,除非切割发生在发育非常年轻的组织中。对这两个物种的研究将确定可能允许动物再生的基因和发育过程,即使它通常不能这样做。确定在哪些特定条件下可以在非再生性物种中引发再生,将有助于进一步了解天然阻挡物对成功再生的影响,并提出绕过这些阻挡物的途径。这项工作将在一个高度支持强有力的指导的环境中培养一批不同的本科生、研究生和研究生研究人员。该实验室已经并将继续向不同的学生提供机会,包括少数族裔等代表性不足的群体。实验室人员将积极参与研究成果的传播,研究成果将及时广泛传播。遗传资源将在获得后不久通过免费提供的序列储存库提供给研究界。

项目成果

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Alexandra Bely其他文献

Alexandra Bely的其他文献

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{{ truncateString('Alexandra Bely', 18)}}的其他基金

EDGE CT: Catalyzing regeneration research by developing functional tools for post-embryonic stages
EDGE CT:通过开发胚胎后阶段的功能工具来催化再生研究
  • 批准号:
    1923429
  • 财政年份:
    2019
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Evolution of regeneration: a comparative study in annelids
再生进化:环节动物的比较研究
  • 批准号:
    0520389
  • 财政年份:
    2005
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant

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