The importance of the postsynaptic signaling scaffolds PSD-95 and PSD-93 for vision and visual plasticity (B05)

突触后蛋白PSD-95和-93在视觉皮层回路的经验依赖性优化中具有相反的功能：PSD-95对于沉默突触的成熟和眼优势可塑性关键时期的关闭是必要的，而PSD-93可以防止突触早熟成熟。两种KO小鼠的定向识别功能均受损，PSD-95 KO小鼠的双眼神经元反应匹配功能受损。为了阐明这些缺陷背后的细胞变化，我们将分析小鼠在学习定向识别任务时的双眼整合和单神经元记录，并研究PSD-95在弱视恢复中的作用。

The postsynaptic proteins PSD-95 and -93 have opposing functions for experience-dependent optimization of visual cortical circuits: While PSD-95 is necessary for maturation of silent synapses and closure of the critical period for ocular dominance plasticity, PSD-93 prevents precocious synaptic maturation. Orientation discrimination was impaired in both KO mice and binocular matching of neuronal responses was impaired in PSD-95 KOs. To clarify the cellular changes underlying these deficits, we will analyze binocular integration and record from single neurons while mice learn an orientation discrimination task, and study the role of PSD-95 for recovery from amblyopia.