MRI: Acquisition of a Modern NMR Spectrometer for the University of Wisconsin - La Crosse Chemistry Department

MRI：为威斯康星大学拉克罗斯化学系购置现代核磁共振波谱仪

• 批准号: 0923388
• 负责人: Adrienne Loh
• 金额: $ 39.03万
• 依托单位: University of Wisconsin-La Crosse
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923388&HistoricalAwards=false
• 关键词: MRI; Acquisition; Modern; NMR; Spectrometer

With this award from the Major Research Instrumentation (MRI) program, Adrienne Loh and her colleague Heather Mortell from University of Wisconsin La Crosse will acquire a 400 MHz NMR spectrometer to support chemical research of faculty at La Crosse as well as Luther College (Decorah, IA). Proposed research spans a number of areas in chemistry, including: 1) protein structure and dynamics; 2) design of siderophore models; 3) discovery of new antimicrobials; 4) characterization of agonist binding sites in serotonin receptor proteins; 5) investigation of organometallic molecular switches; 6) development of soy-bean derived bioplastics and 7) the preparation of inorganic solids as oxidation catalysts. The instrumentation will also be used in teaching and training of undergraduate students in coursework at the University, as well as being an integral part of ongoing outreach activities to middle school and high school students in the area.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry.

有了这个主要研究仪器（MRI）计划的奖项，来自威斯康星州大学拉克罗斯的Adrienne洛和她的同事石楠Mortell将获得一台400 MHz NMR光谱仪，以支持拉克罗斯和路德学院（德科拉，爱荷华州）教师的化学研究。 拟议的研究涵盖化学领域的许多领域，包括： 1)蛋白质结构和动力学; 2）铁载体模型的设计; 3）新抗菌剂的发现; 4）5-羟色胺受体蛋白中激动剂结合位点的表征; 5）有机金属分子开关的研究; 6）大豆衍生生物塑料的开发和7）作为氧化催化剂的无机固体的制备。 该仪器还将用于大学课程的教学和本科生培训，以及该地区正在进行的初中和高中学生外联活动的一个组成部分。核磁共振（NMR）光谱是化学家用于阐明分子结构的最强大的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学和生物化学产生影响。