MRI: Acquisition of a modern single-crystal X-ray diffractometer with a high dynamic range detector

该奖项由主要研究仪器和化学仪器项目支持。来自威斯康辛大学麦迪逊分校的Ilia Guzei教授和他的同事们正在研制一种单晶衍射仪，它配备了一个灵敏的宽视场探测系统和一个铜源。一般来说，x射线衍射仪（XRD）可以精确测量分子的完整三维结构，包括键的距离和角度。XRD还提供了分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响许多领域，包括有机和无机化学，材料化学和生物化学。x射线实验室人员利用衍射仪为代表性不足的少数民族、低收入和/或第一代研究生营造一个包容的氛围。此外，该实验室在加强大学和威斯康辛州公民之间的关系方面发挥着重要作用，通过为中学生和高中生提供外展项目，并与其他项目密切合作，倡导科学、研究和教育对公众的重要性。x射线衍射仪的颁发是我校化学与生物化学专业本科生、研究生和博士后的教学、研究和研究培训的重要组成部分。该仪器采购奖旨在加强各级的研究和教育。XRD将影响到有氧氧化催化剂的开发，以及分子和蛋白质的表征，这些分子和蛋白质通常被称为折叠体。它还用于解码细菌通信和进行对映选择性光催化的研究。衍射仪用于工程生物催化剂，表征过渡金属化合物，以及了解生物活性分子的结构和功能。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Ilia Guzei from the University of Wisconsin-Madison and colleagues are acquiring a single crystal diffractometer equipped with a sensitive wide-field detector system and a copper source. In general, an X-ray diffractometer (XRD) allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles. XRD also provides accurate information about the spatial arrangements of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. The X-ray laboratory personnel utilize the diffractometer to foster an inclusive climate for underrepresented minority, low-income, and/or first-generation graduate students. In addition, the laboratory plays an important role in strengthening the relationship between the University and Wisconsin citizens through an outreach program for middle and high school students and by working closely with other programs advocating the importance of science, research, and education to the public.The award of the X-ray diffractometer is an integral part of teaching as well as research and research training of undergraduate, graduate students and postdoctoral fellows in chemistry and biochemistry at this institution. The instrument acquisition award is aimed at enhancing research and education at all levels. The XRD will impact research areas involving the development of catalysts for aerobic oxidation and the characterization of molecules and proteins that wrap around themselves, commonly called foldamers. It is also used in studies aimed at decoding bacterial communication and for carrying out enantioselective photocatalysis. The diffractometer is used in engineering biocatalysts, characterizing transition metal compounds, and understanding the structure and function of bioactive molecules.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.