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MRI: Acquisition of a modern single-crystal X-ray diffractometer with a high dynamic range detector

MRI：购买带有高动态范围探测器的现代单晶 X 射线衍射仪

基本信息

批准号：
1919350
负责人：
Ilia Guzei
金额：
$ 24.43万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919350&HistoricalAwards=false
关键词：
MRI Acquisition modern single crystal

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Ilia Guzei from the University of Wisconsin-Madison and colleagues are acquiring a single crystal diffractometer equipped with a sensitive wide-field detector system and a copper source. In general, an X-ray diffractometer (XRD) allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles. XRD also provides accurate information about the spatial arrangements of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. The X-ray laboratory personnel utilize the diffractometer to foster an inclusive climate for underrepresented minority, low-income, and/or first-generation graduate students. In addition, the laboratory plays an important role in strengthening the relationship between the University and Wisconsin citizens through an outreach program for middle and high school students and by working closely with other programs advocating the importance of science, research, and education to the public.The award of the X-ray diffractometer is an integral part of teaching as well as research and research training of undergraduate, graduate students and postdoctoral fellows in chemistry and biochemistry at this institution. The instrument acquisition award is aimed at enhancing research and education at all levels. The XRD will impact research areas involving the development of catalysts for aerobic oxidation and the characterization of molecules and proteins that wrap around themselves, commonly called foldamers. It is also used in studies aimed at decoding bacterial communication and for carrying out enantioselective photocatalysis. The diffractometer is used in engineering biocatalysts, characterizing transition metal compounds, and understanding the structure and function of bioactive molecules.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学仪器项目支持。威斯康星大学麦迪逊分校的Ilia Guzei教授和他的同事们正在获得一种单晶衍射仪，该衍射仪配备了一个灵敏的广域探测器系统和一个铜源。通常，X射线衍射仪(X射线衍射仪)可以精确和精确地测量分子的全部三维结构，包括键距离和角度。X射线衍射仪还提供了关于分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响到许多领域，包括有机化学和无机化学、材料化学和生物化学。X射线实验室工作人员利用衍射仪为代表不足的少数族裔、低收入和/或第一代研究生培养包容的氛围。此外，该实验室通过面向初中生和高中生的外展项目以及与其他倡导科学、研究和教育对公众的重要性的项目的密切合作，在加强威斯康星州大学和威斯康星州公民之间的关系方面发挥了重要作用。授予X射线衍射仪是该机构化学和生物化学本科生、研究生和博士后研究员教学以及研究和研究培训的组成部分。仪器采购奖旨在加强各级的研究和教育。X射线衍射仪将影响研究领域，包括有氧氧化催化剂的开发，以及自我包裹的分子和蛋白质的表征，通常被称为折叠体。它还被用于旨在解码细菌通信和进行对映选择性光催化的研究中。衍射仪用于工程生物催化剂，表征过渡金属化合物，以及了解生物活性分子的结构和功能。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Phase diagrams of aqueous solutions of the potassium salts of malonic, succinic, and glutaric acids

丙二酸、琥珀酸和戊二酸的钾盐水溶液的相图

DOI：
10.1016/j.jct.2021.106466
发表时间：
2021
期刊：
The Journal of Chemical Thermodynamics
影响因子：
0
作者：
Roskam, Julia L.;Nowak, Kristen L.;Taylor, Karl T.;Rendler, Samuel R.;Beyer, Keith D.
通讯作者：
Beyer, Keith D.

Triple, Mutually Orthogonal Bioorthogonal Pairs through the Design of Electronically Activated Sulfamate-Containing Cycloalkynes.