MRI: Acquisition of Solexa Genome Analyzer to enable collaborative molecular, environmental, and computational research

MRI：收购 Solexa 基因组分析仪以实现协作分子、环境和计算研究

• 批准号: 0923513
• 负责人: Sergey Nuzhdin
• 金额: $ 56.3万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923513&HistoricalAwards=false
• 关键词: MRI; Acquisition; Solexa; Genome; Analyzer

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).New revolutionary technologies have been developed enabling scientists with the ability to rapidly determine the sequence of large amounts of DNA. This will allow scientists in nearly all biological disciplines to rapidly move forward on projects that seek to understand the molecular basis of disease and development, to understand how differences at the DNA level leads to differences in individuals in a population, and to understand at a molecular level the different organisms that contribute both positively and negatively to the environment. This type of knowledge will have profound impacts on our understanding of basic biology and how variations in DNA sequence influence whether an individual gets a disease or how differences in ecological niches results in changes to the environment. The acquisition of a next-generation sequencing machine will allow a broad group of scientists at University of Southern California to address all of these types of questions with scientists that span the disciplines of Molecular and Computational Biology, Marine Environmental Biology and Neurobiology. The administration at University of Southern California has fostered an environment of innovation and collaboration, which is critical for success in the use of this next-generation platform, since the generation and analyses of this data requires expertise in very disparate academic discipline. In addition, one of the primary goals of faculty at University of Southern California is training the next generation of scientists and the acquisition of the next-generation sequencing machine will ensure that these students receive the most cutting-edge training. The purchase of the sequencing machine will tie in with the Center for Excellence and Genomics at University of Southern California that has a robust training program that ensures that underrepresented minorities are trained in cutting edge biology using genomic and computational approaches.

该奖项由 2009 年美国复苏和再投资法案（公法 111-5）资助。新的革命性技术的开发使科学家能够快速确定大量 DNA 的序列。 这将使几乎所有生物学科的科学家能够快速推进旨在了解疾病和发育的分子基础的项目，了解DNA水平的差异如何导致人群中个体的差异，并在分子水平上了解对环境有积极和消极贡献的不同生物体。 这类知识将对我们对基础生物学以及 DNA 序列的变化如何影响个体是否患病或生态位的差异如何导致环境变化的理解产生深远的影响。 购买下一代测序机将使南加州大学的众多科学家能够与分子和计算生物学、海洋环境生物学和神经生物学等学科的科学家一起解决所有这些类型的问题。南加州大学的管理部门营造了一个创新和协作的环境，这对于成功使用这一下一代平台至关重要，因为这些数据的生成和分析需要非常不同的学科的专业知识。 此外，南加州大学教师的首要目标之一是培训下一代科学家，购买下一代测序机将确保这些学生接受最前沿的培训。 测序机的购买将与南加州大学卓越和基因组学中心合作，该中心拥有强大的培训计划，可确保代表性不足的少数群体接受使用基因组和计算方法的尖端生物学培训。