Planning Visit to the National Institute of Materials Science, Japan; To Establish Collaborative Research on Nanoscale Adsorption of Amyloid Beta Peptides

计划访问日本国立材料科学研究所；

• 批准号: 0929615
• 负责人: Kazushige Yokoyama
• 金额: $ 0.58万
• 依托单位: SUNY College at Geneseo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2011-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0929615&HistoricalAwards=false
• 关键词: Planning; Visit; National; Institute; Materials

The PI's research group at the State University of New York College at Geneseo discovered that the alpha-beta coated gold metal colloid exhibits a quasi-repetitive color change between pH 4 and pH 10, in which a short-lived intermediate of the self assembly created only at an interfacial condition was involved. In this collaborative project, the conformation of alpha-beta aggregates binding to the functionalized gold colloid surface will be directly investigated by utilizing high-resolution transmission electric microscopy at Japan's National Institute of Materials Science, in order to directly clarify the structure at a nanometer scale. This study will answer 1) why the observed pH induced quasi-reversible process takes place only for 20 nm gold colloid and 2) why an effective cage-like conformation of alpha-beta is observed at only 40 and 80 nm gold colloid. Results could lead to the development of highly selective biosensors and have a long term biomedical engineering impact in the areas of cancer treatment and nanomedicine. This project is the preparatory stage for a long-term international research collaboration in which top notch American undergraduates will gain international research experience and be exposed to innovative biomedical engineering technology.

Geneseo纽约州立大学的PI研究小组发现，Alpha-Beta涂层金属胶体在pH 4和pH 10之间表现出准重复的颜色变化，其中仅涉及在界面条件下创建的自给自足的短暂中间体。在这个协作项目中，将直接研究与功能化金胶体表面结合的α-beta聚集体的构象，通过利用日本国家材料科学研究所的高分辨率传输电动显微镜直接研究，以直接以纳米计尺度阐明结构。这项研究将回答1）为什么观察到的pH诱导的准可逆过程仅发生20 nm金胶体，以及2）为什么仅在40和80 nm的金胶体下观察到有效的alpha-beta的有效笼子样构象。结果可能导致高度选择性生物传感器的发展，并在癌症治疗和纳米医学领域具有长期的生物医学工程影响。该项目是一项长期国际研究合作的准备阶段，在该合作中，一流的美国大学生将获得国际研究经验，并接触创新的生物医学工程技术。