权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Overseas Travel Grant: From Dendralenes to Antimicrobial Decalins (Visit to Research School of Chemistry, Australian National University)

海外旅费资助：从Dendralenes到抗菌十氢萘（参观澳大利亚国立大学化学研究院）

基本信息

批准号：
EP/R024758/1
负责人：
Paul Clarke
金额：
$ 1.49万
依托单位：
University of York
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FR024758%2F1
关键词：
Overseas Travel Grant Dendralenes Antimicrobial

项目摘要

Bacterial infections are becoming increasingly hard to treat with current antibiotics and it is well recognised that new treatments are required. The government and the WHO continue to highlight the development of new antibiotics as an area of high priority. Many antimicrobial natural products contain functionalised decalin ring systems. These structural units are synthetically non-trivial to construct and oftentimes require many synthetic steps. It is proposed here that recent advances in the synthesis and characterisation of dendralenes may enable the development of a highly efficient and general transmissive Diels-Alder approach to a large range of functionalised decalin ring systems present in many natural products. If successful, such a route could lead to breakthroughs in the synthesis and supply of these scarce molecules for full biological evaluation. This proposal will build on our previous EPSRC-funded work in the area antimicrobial natural product synthesis and the use of Diels-Alder reactions for the synthesis of biologically active natural products by allowing the PI to spend a period of time embedded in the Sherburn group to gain first-hand experience in the synthesis and handling of dendralenes. This will enable a full proposal for the use of dendralenes in the synthesis of decalin-containing antimicrobials to be developed.

细菌感染正变得越来越难以用现有的抗生素治疗，人们普遍认为需要新的治疗方法。政府和世卫组织继续强调开发新抗生素是一个高度优先的领域。许多抗微生物天然产物含有官能化的十氢化萘环系统。这些结构单元在合成上是不易构建的，并且通常需要许多合成步骤。在这里提出，最近的进展，在合成和表征的dendralene可能使一个高效的和一般的透射狄尔斯-阿尔德方法的发展，以大范围的功能化十氢萘环系统存在于许多天然产物。如果成功的话，这种途径可能会导致这些稀缺分子的合成和供应方面的突破，以进行全面的生物学评估。该提案将建立在我们之前在抗菌天然产物合成和使用Diels-Alder反应合成生物活性天然产物领域的EPSRC资助工作的基础上，允许PI花一段时间嵌入舍伯恩小组，以获得合成和处理dendralene的第一手经验。这将使一个完整的建议，使用dendralenes在合成含萘烷的抗菌剂被开发。