Classical and instrumental conditioning of brain-communication and neuronal connectivity

大脑通讯和神经元连接的经典和仪器调节

• 批准号: 194168023
• 负责人: Professor Dr. Niels Birbaumer
• 金额: --
• 依托单位: Institut für Medizinische Psychologie und Verhaltensneurobiologie
• 依托单位国家: 德国
• 项目类别: Reinhart Koselleck Projects
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/194168023?language=en
• 关键词: Classical; instrumental; conditioning; brain; communication

Here, the unresolved problem of semantic and emotional brain communication with the completely paralyzed, very small children and patients with advanced dementia will be investigated by using twoprocess (classical – operant) learning of evoked and oscillatory brain activity and real-time pattern classification of emotional brain responses with recording of metabolic (BOLD) and neuroelectric (EEG) signals. Second, since goal directed sensorimotor behavior results from dynamic connectivity patterns in large neuronal assemblies instrumental (reward) learning of such brain connectivity patterns with real-time functional magnetic resonance imaging (rt-fMRI), near infrared spectroscopy (NIRS) and magnetoencephalography (MEG)/EEG-cross-coherence is performed using psychopathic behavior and pedophilic behavior disorder, and eating in lean and obese persons as model systems of particularly high change-resistant brain-behavior patterns. To improve learning and neural plasticity non-invasive transcranial DC-stimulation (tDCS) will be used in some of the experimental conditions. While braincomputer- interface (BCI) research has a short tradition in the cognitive neurosciences the proposed project and methodology cannot rely on previous scientific tradition: only the Koselleck grant application scheme is appropriate for this situation. In addition to the clinical purpose in providing new and probably more efficient non-invasive behavioral therapeutic solutions for these treatment-resistant disorders the proposed experiments provide insight into some fundamental theoretical problems: a) The “restoration” of volition (instrumental behaviour) after prolonged paralysis and extinction of goal directed behavior and thought b) The development of volition at the beginning of life and during the terminal phases of cognitive human life. c) The optimal learning schemas for encoding and modification of repetitive destructive and autodestructive behaviors and their brain activation patterns such as instrumental aggression in psychopathy and overeating. d) Which patterns of interconnected brain activity are indispensable for the reconstruction of these change-resistant behaviors?

在这里，我们将通过对诱发和振荡脑活动的两过程（经典-操作）学习，以及记录代谢（BOLD）和神经电（EEG）信号的情绪脑反应的实时模式分类，来研究完全瘫痪、非常小的儿童和晚期痴呆患者的语义和情绪脑交流的尚未解决的问题。其次，由于目标导向的感觉运动行为是由大型神经元集合的动态连接模式产生的，因此使用实时功能磁共振成像（rt-fMRI）、近红外光谱（NIRS）和脑磁图(MEG)/脑电图交叉一致性对这种大脑连接模式进行了工具（奖励）学习，研究对象是精神病行为和恋童癖行为障碍。瘦人和肥胖者的饮食模式具有特别高的抗变化大脑行为模式。为了提高学习能力和神经可塑性，将在一些实验条件下采用无创经颅直流刺激（tDCS）。虽然脑机接口（BCI）研究在认知神经科学中具有较短的传统，但所提出的项目和方法不能依赖于以前的科学传统：只有Koselleck资助申请计划适合于这种情况。除了为这些难治性疾病提供新的、可能更有效的非侵入性行为治疗方案的临床目的之外，拟议的实验还提供了对一些基本理论问题的见解：a)在长期的麻痹和目标导向的行为和思想的消失之后，意志（工具性行为）的“恢复”b)在生命的开始和人类认知生命的最后阶段，意志的发展。c)重复破坏性和自破坏性行为编码和修正的最佳学习模式及其脑激活模式，如精神变态的工具攻击和暴饮暴食。d)哪些相互关联的大脑活动模式对于这些抵抗变化的行为的重建是不可或缺的？