Physiological Regulation of Chronic Tinnitus

慢性耳鸣的生理调节

• 批准号: 290833054
• 负责人: Professor Dr. Niels Birbaumer
• 金额: --
• 依托单位: Fakultät für Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/290833054?language=en
• 关键词: Physiological; Regulation; Chronic; Tinnitus

Chronic tinnitus co-varies with a decrease of inhibition of the central auditory system. This project investigates a new rehabilitation strategy using training of local neuronal inhibition in the auditory system with local alpha-EEG-neurofeedback: 3 comparable randomized groups of 30 patients each suffering from chronic tinnitus receive (1) Neurofeedback of local auditory alpha-rhythm with simultaneous alpha-blockade in the somatosensory and visual projection areas of the brain in order to revive physiological inhibition in the auditory system in the experimental group (EG), (2) receive identical training as the EG but without association (contingency) between auditory cortex alpha and feedback in the control group (CG) and (3) receive cognitive behavior therapy (CBT) of the tinnitus in the third group. We expect that the EG shows a neurophysiological and behavioral and perceptual stable reduction of tinnitus and that local neuronal inhibition (alpha) and cortical reorganization of the auditory system reflect the behavioral improvement of the rehabilitation training.

慢性耳鸣与中枢听觉系统抑制作用的降低共同变化。本项目研究了一种新的康复策略，利用听觉系统局部神经元抑制训练和局部α -脑电图神经反馈：慢性耳鸣患者随机分为3组，每组30例，分别接受(1)在大脑体感区和视觉投射区同时阻断局部听觉α节律的神经反馈，以恢复听觉系统的生理抑制（EG）；(2)对照组（CG）接受与EG相同的训练，但听觉皮层α与反馈之间没有关联（偶然性）；(3)第三组接受耳鸣认知行为治疗（CBT）。我们期望eeg显示耳鸣的神经生理、行为和知觉稳定的减少，听觉系统的局部神经元抑制（α）和皮层重组反映了康复训练的行为改善。

项目成果

Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus

实时监测和调节慢性耳鸣患者听觉皮层α活性

• DOI: 10.1088/1741-2552/ab57d5
• 发表时间: 2020
• 期刊: Journal of Neural Engineering
• 影响因子: 4
• 作者: Malekshahi;Malekshahi;Czornik;Wolpert;Birbaumer
• 通讯作者: Birbaumer