DDEP: U.S.-Finland: Tracking Echovirus I Early Entry into Host Cells

0935271Huser这项对国际博士论文增强项目(DDEP)的支持将使加州大学戴维斯分校的生物物理学研究生Gregory McNerney前往芬兰，与专家合作研究ECHO病毒(EV1)的成像研究，EV1是一种人类病原体病毒。目的是与芬兰一个备受尊敬的团队一起研究EV1的进入，该团队由Jyveskyla大学的Varpu Marjomaki博士领导，他研究了调节内细胞膜运输的分子机制。此外，她和她所在机构的同事都是模型系统、分析软件和光学探测器的创新开发人员。在他的芬兰东道主S实验室期间，麦克纳尼？S计划通过开源软件平台BioImageXD测试光学成像分析工具，该平台将用于获得关于共址、尺寸测量和扩散速率的新数据。因此，DDEP将为美国学生提供理想的、职业生涯早期接触到欧洲领先的病毒学专业知识、技术和工具的机会。此外，该项目有望巩固Marjomaki？S博士研究小组与McNerney？S物理学家顾问、加州大学戴维斯分校Thomas Huser博士之间充满希望的合作，后者的研究小组致力于高速和高分辨率活细胞成像的先进方法。通过参与芬兰团队？S对BioImageXD功能的改进和软件？S健壮性，McNerney先生应该会在使用EV1病毒作为模型病毒的同时，对细胞摄取途径有新的见解。如果成功，联合项目的结果和改进的图像分析技术可能会使更广泛的研究界受益，包括对EV1样感染和自我复制感兴趣的其他生物学学生和医学研究人员。

0935271HuserThis support for an international doctoral dissertation enhancement project (DDEP) will enable biophysics graduate student, Gregory McNerney from the University of California-Davis, to travel to Finland for cooperative work with experts on imaging studies of Echovirus (EV1), a human pathogen virus. The purpose is to study EV1 entry with a highly regarded team in Finland, headed by Dr. Varpu Marjomaki at the University of Jyvaskyla, who has studied the molecular mechanisms that regulate endocytic membrane traffic. Furthermore, she and colleagues at her institution are innovative developers of model systems, analysis software, and optical probes. While at his Finnish host?s laboratory, Mr. McNerney?s plans include the testing of analysis tools for optical imaging via the open-source software platform BioImageXD which will be used to obtain new data on colocalization, size measurements and diffusion rates. Thus, the DDEP will provide the U.S. student with desirable, early career access to leading European virology expertise, techniques, and tools. Furthermore, the project is expected to solidify a promising collaboration between Dr. Marjomaki?s research group and that of McNerney?s physicist advisor, Dr. Thomas Huser at UC- Davis, whose research group works on advanced approaches to live cell imaging at high speed and high resolution.Through participation in the Finnish team?s refinement of BioImageXD functions and the software?s robustness, Mr. McNerney should gain new insights about cellular uptake pathways while using EV1 as a model virus. If successful, results from the joint project and improved image analysis techniques could benefit the broader research community, including other biology students and medical investigators who have interest in EV1-like infections and self-replication.