CDI-Type 1: Physical and Chemical Alignment of Multiple Protein Surfaces

CDI-类型 1：多个蛋白质表面的物理和化学排列

• 批准号: 0941013
• 负责人: Michael Gleicher
• 金额: $ 63.07万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0941013&HistoricalAwards=false
• 关键词: CDI; Type; Physical; Chemical; Alignment

Proteins are central to carrying out life?s processes and provide the link between genetic information and biological function. Understanding protein action is critical in understanding biology at a molecular level: improving our knowledge has applications ranging from developing drugs to synthesizing biofuels. This project will develop a new approach for studying protein action based on comparing the detailed chemical and physical properties that the molecules create. This new approach will provide better techniques for finding related molecules, or understanding the differences between similar ones. Better matching techniques will enable new tools for inferring the function of uncharacterized proteins, designing proteins to achieve specific goals, and studying evolutionary relationships.This project will lead to new coursework in visual computing and biochemistry, contribute to training undergraduates and graduate students, and provide outreach to K-12 science education.

蛋白质是维持生命的核心？的过程，并提供遗传信息和生物功能之间的联系。了解蛋白质的作用对于在分子水平上理解生物学至关重要：提高我们的知识可以应用于从开发药物到合成生物燃料的各种应用。该项目将开发一种新的方法来研究蛋白质的行动的基础上比较详细的化学和物理性质的分子创建。 这种新方法将为寻找相关分子或了解相似分子之间的差异提供更好的技术。 更好的匹配技术将使新工具能够推断未表征蛋白质的功能、设计蛋白质以实现特定目标以及研究进化关系。该项目将带来视觉计算和生物化学的新课程，有助于培训本科生和研究生，并为K-12科学教育提供外展服务。