Collaborative Research: Engineering Genetically Augmented Polymers (GAPS)
合作研究:工程基因增强聚合物 (GAPS)
基本信息
- 批准号:0943393
- 负责人:
- 金额:$ 57.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Synthetic biology is an emerging field that involves the design or re-design and manufacture of new biologically-inspired parts, modules, devices and systems. This has two major outputs. First, it tests scientific understanding of how life works and how it can be re-engineered at the most fundamental level. Second, it promises to put biological systems on a more modular and rational footing for subsequent engineering efforts. Foundational technologies need to be developed to make synthetic biology modular, scalable, and programmable. This project seeks to address this challenge by expanding biological space with Genetically Augmented PolymerS (GAPS) that will enable the design and manufacture of programmable networks and novel chemical function. Nucleobase amino acids (NAAs) will be synthesized and incorporated into natural polymers, proteins (pGAPS), and chemical polymers, polyvinyl nucleobases (cGAPS). In essence, by giving proteins and cells the ability to 'talk' with one another using the same code that DNA and RNA uses this proposal seeks to create a programmable ur-cell for biomedical engineering. This work will catalyze a new paradigm for engineering both chemical and biological systems. By melding the complexity and diversity of Biology with the predictability and high scalability of Chemistry, GAPS will pioneer new directions in synthetic biology. The addition of genetic information to proteins and cells will in general make biology more modular, scalable, and programmable. This should in turn enable the rational design and re-design of biological systems for compelling applications, such as controlling the wiring of interactomes and rationally modulating and programming cell function. For example, it should be possible to re-wire signaling pathways on a protein-by-protein basis, and to engineer tissues in a way that allows the precise, genetically-encoded placement of individual cells. Broader impact: In addition to creating a wholly new ur-cell platform for synthetic biology applications, the formation of a strong a UK-US team will have a considerable impact on the global leadership by these two countries in synthetic biology. The readily grasped goals of this project (programmable cells, replicating plastic) will provide opportunities for showing the public that synthetic biology is a field that yields translational technologies that can impact their own lives. Following up on the goals of the Sandpit, the international research team will establish and maintain a valuable network that provides for competitive, interdisciplinary, and globally-engaged research. This network will directly reach out to and involve students in synthetic biology (via iGEM, the Freshman Research Initiative, and "Current Protocols in Synthetic Biology"), and will begin to train a new generation of engineers who are comfortable operating between disciplines, labs, and continents. Moreover, the network will be of great use in engaging public interest and educating policy makers about the threats and benefits of synthetic biology, overall raising awareness of the ethical, legal and social impacts of synthetic biology.
合成生物学是一个新兴领域,涉及设计或重新设计和制造新的生物启发的部件,模块,设备和系统。这有两个主要产出。首先,它测试了对生命如何运作以及如何在最基本的层面上重新设计的科学理解。其次,它有望为后续的工程工作将生物系统置于更加模块化和合理的基础上。需要开发基础技术,使合成生物学模块化,可扩展和可编程。该项目旨在通过使用遗传增强聚合物(GAPS)扩展生物空间来应对这一挑战,这将使可编程网络和新型化学功能的设计和制造成为可能。核碱基氨基酸(NAAs)将被合成并掺入天然聚合物、蛋白质(pGAPS)和化学聚合物、聚乙烯核碱基(cGAPS)中。从本质上讲,通过赋予蛋白质和细胞使用DNA和RNA使用的相同代码相互“交谈”的能力,该提案旨在为生物医学工程创造可编程的ur-cell。这项工作将为化学和生物系统的工程设计提供一个新的范例。通过将生物学的复杂性和多样性与化学的可预测性和高度可扩展性相结合,GAPS将开创合成生物学的新方向。将遗传信息添加到蛋白质和细胞中通常会使生物学更加模块化,可扩展和可编程。这将反过来使生物系统的合理设计和重新设计成为可能,以实现引人注目的应用,例如控制相互作用组的布线以及合理地调节和编程细胞功能。例如,应该有可能在蛋白质的基础上重新连接信号通路,并以一种允许个体细胞精确的遗传编码放置的方式设计组织。更广泛的影响:除了为合成生物学应用创建一个全新的ur-cell平台外,组建一支强大的英美团队将对这两个国家在合成生物学领域的全球领导地位产生相当大的影响。这个项目的目标(可编程细胞,复制塑料)将提供机会向公众展示合成生物学是一个产生可以影响他们自己生活的转化技术的领域。为了实现Sandpit的目标,国际研究团队将建立和维护一个有价值的网络,为竞争性的、跨学科的和全球参与的研究提供支持。该网络将直接接触并参与合成生物学的学生(通过iGEM,新生研究计划和“合成生物学当前协议”),并将开始培养新一代工程师,他们可以在学科,实验室和大陆之间轻松操作。此外,该网络将在吸引公众兴趣和教育决策者了解合成生物学的威胁和好处方面发挥巨大作用,全面提高对合成生物学的伦理、法律的和社会影响的认识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Jewett其他文献
MP67-20 IDENTIFYING BARRIERS TO THE ADOPTION OF PERCUTANEOUS RENAL TUMOUR BIOPSY IN THE MANAGEMENT OF SMALL RENAL MASSES
- DOI:
10.1016/j.juro.2017.02.2056 - 发表时间:
2017-04-01 - 期刊:
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Patrick O. Richard;Lisa Martin;Luke Lavallée;Phil Violette;Maria Komisarenko;Kunal Jain;Michael Jewett;Antonio Finelli - 通讯作者:
Antonio Finelli
1182 GROWTH KINETICS OF SMALL RENAL MASSES: A PROSPECTIVE ANALYSIS FROM THE RENAL CELL CARCINOMA CONSORTIUM OF CANADA
- DOI:
10.1016/j.juro.2013.02.2536 - 发表时间:
2013-04-01 - 期刊:
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Michael Organ;Michael Jewett;Mohamed Abdolell;Joan Basiuka;Neil Fleshner;Antonio Finelli;Christopher Morash;Stephen Pautler;Joseph Chin;Robert Siemens;Simon Tanguay;Martin Gleave;Darrel Drachenberg;Raymond Chow;Andrew Evans;Brenda Gallie;Masoom Haider;John Kachura;Ricardo Rendon - 通讯作者:
Ricardo Rendon
1476 PATIENTS WITH NON PRIMARY PT1 NON-MUSCLE INVASIVE BLADDER CANCER (NMI-BC) TREATED WITH BACILLUS CALMETTE-GUERIN (BCG) ARE AT HIGHER RISK OF PROGRESSION COMPARED TO PRIMARY T1 TUMORS
- DOI:
10.1016/j.juro.2010.02.1191 - 发表时间:
2010-04-01 - 期刊:
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- 作者:
Sultan Alkhateeb;Bas Van Rhijn;Antonio Finelli;Theodorus van der Kwast;Andrew Evans;Sally Hanna;Rati Vajpeyi;Neil Fleshner;Michael Jewett;Alexandre Zlotta - 通讯作者:
Alexandre Zlotta
MP28-12 MOLECULAR MARKERS (FGFR3 MUTATION; P53 & KI-67 EXPRESSION) AND CLINICAL OUTCOME OF RADICAL CYSTECTOMY FOR BLADDER CANCER: A MULTICENTER, MULTILAB STUDY
- DOI:
10.1016/j.juro.2014.02.661 - 发表时间:
2014-04-01 - 期刊:
- 影响因子:
- 作者:
Laura Mertens;Tahlita Zuiverloon;Yann Neuzillet;Shahrokh Shariat;Cheno Abas;Peter Bostrom;Marcel Vermeij;Tuomas Mirtti;Arthur Sagalowsky;Joost Boormans;Dennis Peters;Raheela Ashfaq;Jeroen de Jong;Annegien Broeks;Neil Fleshner;Simon Horenblas;Arno van Leenders;Bharati Bapat;Michael Jewett;Alexandre Zlotta - 通讯作者:
Alexandre Zlotta
1677 NATURAL HISTORY OF RENAL FUNCTION IN UNTREATED KIDNEY CANCER
- DOI:
10.1016/j.juro.2012.02.1550 - 发表时间:
2012-04-01 - 期刊:
- 影响因子:
- 作者:
Ashraf Almatar;David Margel;Antonio Finelli;Hannah Chung;Neil Fleshner;Alexandre Zlotta;Laura Legere;Henry Ajzenberg;Michael Jewett - 通讯作者:
Michael Jewett
Michael Jewett的其他文献
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{{ truncateString('Michael Jewett', 18)}}的其他基金
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合作研究:用于即时疫苗生物制造的无细胞糖蛋白合成技术
- 批准号:
2341123 - 财政年份:2023
- 资助金额:
$ 57.64万 - 项目类别:
Continuing Grant
Collaborative Research: Cell-free glycoprotein synthesis technology for point-of-care vaccine biomanufacturing
合作研究:用于即时疫苗生物制造的无细胞糖蛋白合成技术
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1936789 - 财政年份:2020
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Collaborative Research: Repurposing the translation apparatus for mirror image polypeptide synthesis
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1716766 - 财政年份:2017
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Standard Grant
Synthetic Biology, Engineering, Evolution & Design 2016 (SEED 2016), Chicago, IL, July 18-21, 2016
合成生物学、工程学、进化论
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1634295 - 财政年份:2016
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Standard Grant
Collaborative Research: Glycoengineering Without Borders: Bacterial Cell-Free Glycoprotein Synthesis
合作研究:无国界糖工程:细菌无细胞糖蛋白合成
- 批准号:
1413563 - 财政年份:2014
- 资助金额:
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Materials World Network: Chemical and BIological Approaches to Sequence Controlled Polymers
材料世界网络:序列控制聚合物的化学和生物方法
- 批准号:
1108350 - 财政年份:2011
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International Research Fellowship Program: Systems Biology of Glucose Repression in Yeast for Metabolic Engineering
国际研究奖学金计划:代谢工程酵母中葡萄糖抑制的系统生物学
- 批准号:
0504168 - 财政年份:2005
- 资助金额:
$ 57.64万 - 项目类别:
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