Cell-Free Systems Conference

无细胞系统会议将于2019年12月4日至6日在马萨诸塞州波士顿举行。这次会议是第一次在美国举行的会议，讨论无手机平台的成就和挑战。在美国化学工程师协会（AIChE）的主持下，这次国际会议将汇集知名专家、知名研究人员、年轻研究人员、私营部门的科学家和工程师以及研究生，以评估无细胞系统技术的现状，并确定放弃传统代谢工程的挑战。生物制造是一种生产能源、农业和医药领域使用的大量化学品的常用方法。从历史上看，合成这些化学物质所需的途径已经通过基因工程进入酵母和细菌等活细胞。这种方法经常受到细胞中已经存在的其他途径的阻碍，导致产量低和/或细胞死亡。无细胞系统方法旨在利用合成生物学来重建细胞外合成所需化学物质所需的最小转录和翻译机制，从而绕过复杂活细胞内固有的调节反馈和抑制。更具体地说，本次会议将讨论有关无细胞系统在制造、小分子和治疗性蛋白质发现、原型设计、诊断和教育方面的现状的重要问题。会议的论文集将经同行评审，并在美国医学会网站上向公众发布。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The Cell-Free Systems Conference will be held in Boston, Massachusetts on December 4-6, 2019. This conference is the first one to be held in the United States that addresses the achievements and challenges of cell-free platforms. Organized under the auspices of the American Institute of Chemical Engineers (AIChE), this international conference will bring together renowned experts, established researchers, young investigators, private sector scientists and engineers, and graduate students to assess the state of cell-free system technologies and to identify the challenges of abandoning traditional metabolic engineering. Biological manufacturing is a common method to produce a vast array of chemicals used in the fields of energy, agriculture, and medicine. Historically, the pathways required to synthesize these chemicals have been genetically engineered into living cells such as yeast and bacteria. This approach is often hindered by other pathways already present in the cell, leading to low production yield and/or cell mortality. A cell-free systems approach aims to use synthetic biology to recreate the minimal transcriptional and translational machinery requisite to synthesize a desired chemical outside of a cell, therefore bypassing the regulatory feedback and suppression inherent within a complex living cell. More specifically, this conference will address important issues regarding the current state of cell-free systems in manufacturing, small molecule and therapeutic protein discovery, prototyping, diagnostics, and education. The proceedings of the conference will be peer-reviewed and disseminated to the public on AIChE's website.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.