SBIR Phase I: A protein-based biofungicide for agricultural use

SBIR 第一阶段：基于蛋白质的农业生物杀菌剂

• 批准号: 0944433
• 负责人: Ryan Shepherd
• 金额: $ 15万
• 依托单位: PhylloTech Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0944433&HistoricalAwards=false
• 关键词: SBIR; Phase; protein; based; biofungicide

This SBIR Phase I project will develop a plan to use a protein normally produced in plants, to control phytopathogenic fungi. They have cloned a gene that encodes for this protein, expressed it in bacterial vectors, demonstrated activity against three phytopathogenic fungi, demonstrated activity on a grass, and they have done RNA interference to show that this gene is responsible to confer protection in plants.The broader/commercial impact of the project will be the targeted use for organic farms. The properties of this compound seem appropriate for that use. The results of these studies will demonstrate that protein-based biofungicides are possible and they will have implications for understanding the importance of preformed plant defenses in the disruption of pathogen infection strategies.

这个SBIR第一阶段项目将制定一项计划，使用一种通常在植物中产生的蛋白质来控制植物病原真菌。他们已经克隆了这种蛋白的编码基因，在细菌载体中表达了它，展示了对三种植物病原真菌的活性，展示了对一种草的活性，他们还进行了RNA干扰，以表明该基因对植物具有保护作用。该项目的更广泛/更广泛的商业影响将是针对有机农场的使用。这种化合物的性质似乎适合那种用途。这些研究的结果将证明基于蛋白质的生物杀菌剂是可能的，它们将有助于理解预先形成的植物防御系统在破坏病原体感染策略方面的重要性。