SBIR Phase I: Reduced Noise Bioelectrode for Improved Detection and Imaging

SBIR 第一阶段：降低噪音的生物电极以改善检测和成像

• 批准号: 0945118
• 负责人: Konstantine Ermolaev
• 金额: $ 14.76万
• 依托单位: Quantum Applied Science & Research, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0945118&HistoricalAwards=false
• 关键词: SBIR; Phase; Reduced; Noise; Bioelectrode

This Small Business Innovation Research Phase I project will investigate whether a new type of bioelectrode can provide lower noise on the skin than the current state-of-the-art Ag/AgCl electrodes. Even after extensive skin cleaning and abrasion, the noise level of present technology is approximately ten times higher than the internal electronic noise of the first stage amplifier. Preliminary experiments with a lash-up version of the new electrode showed an immediate factor of two improvement in sensitivity. Arguments based on the performance of the new materials underwater suggest a factor of ten reduction in measurement noise might be achieved. This Phase I project will test a set of the new electrodes made under different conditions on a range of subjects with the goal of defining a protocol to best exploit the new approach. Based on the results and in collaboration with four academic medical researchers, the benefits in specific research and medical applications will be quantified. The broader/commercial impact is that reduced measurement noise in biolectrodes offers the capability to record and discriminate signals too weak to be currently measurable, and localize and separate sources to small to be resolved. Bioelectrodes are used extensively in research and medicine for recording the electrical activity of the body (e.g. the heart, brain, and general muscle activation). If successful, this SBIR offers a basic advance in science and technology that is applicable in many areas. There are around 1000 laboratories worldwide studying brain electrical activity that could gain substantial benefit from improved electrode sensitivity. As research progresses and demonstrates clinical utility, the standard path is for new research advances to be adopted into clinical practice, creating much larger markets. In addition significant clinical markets exist for cardiac diagnosis involving small signals such as the P-wave and T-wave of the electrocardiogram.

这个小型企业创新研究第一阶段项目将研究一种新型的生物电极是否可以提供比目前最先进的Ag/AgCl电极更低的皮肤噪音。即使在广泛的皮肤清洁和磨损之后，本技术的噪声水平也比第一级放大器的内部电子噪声高大约十倍。用新电极的应急版本进行的初步实验表明，灵敏度的两个直接因素提高了。基于水下新材料性能的争论表明，测量噪声可能会降低10倍。 该第一阶段项目将在一系列受试者身上测试在不同条件下制造的一组新电极，目的是定义一个协议，以最好地利用新方法。根据研究结果，并与四名学术医学研究人员合作，将量化具体研究和医疗应用中的效益。更广泛的/商业影响是，生物电极中降低的测量噪声提供了记录和区分太弱而当前无法测量的信号的能力，以及定位和分离小到无法分辨的源的能力。生物电极广泛用于研究和医学中，用于记录身体的电活动（例如心脏，大脑和一般肌肉激活）。 如果成功的话，这一SBIR提供了适用于许多领域的科学和技术的基本进步。 全世界大约有1000个实验室在研究脑电活动，这些实验室可以从提高电极灵敏度中获得实质性的好处。随着研究的进展和临床效用的展示，标准的路径是将新的研究进展应用于临床实践，创造更大的市场。此外，对于涉及诸如心电图的P波和T波的小信号的心脏诊断存在重要的临床市场。