SBIR Phase I: Versatile Hand Held Nanosensory Pathogen Detection Device for Real-Time Diagnosis

SBIR 第一阶段：用于实时诊断的多功能手持式纳米感觉病原体检测设备

• 批准号: 0945863
• 负责人: Agenor Mafra-Neto
• 金额: $ 14.82万
• 依托单位: ISCA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0945863&HistoricalAwards=false
• 关键词: SBIR; Phase; Versatile; Hand; Held

This Small Business Innovation Research (SBIR) Phase I project aims to develop a palmtop device to accurately detect and report in real-time the analytes, pathogens and contaminants in the field. The approach is to integrate (1) antibody functionalized conducting nanosensors; (2) an automated robotic sample manipulation/preparation device; and (3) a low energy, high throughput, miniaturized electromechanical system with user interface for data integration and reporting. This project will address the nanosensory detection of Borrelia burgdorferi, the etiologic agent of Lyme disease, the most prevalent tick-borne illness in the United States. The broader/commercial impact of this project will be the potential to provide a device for vector and disease management, biodetection in homeland security, health care, agroenvironmental applications and food safety markets. It is believed that an early detection is the best solution to prevent epidemics. In the case of Lyme disease, current detection of Borrelia burgdorferi is slow, expensive and requiring constant human interference and laboratory conditions, resulting in only a small portion of the introduced pathogens actually being detected before diseases or epidemics become widespread. This project will enable the efficient in-field monitoring for the presence of Lyme disease and other pathogens. The data will be wireless transferred to a centralized hub, providing decision-makers with real-time intelligence of field conditions and allowing time for preventive rather than crisis control actions.

该小型企业创新研究（SBIR）第一阶段项目旨在开发一种掌上设备，以准确检测和实时报告现场的分析物，病原体和污染物。 该方法是整合（1）抗体功能化的导电纳米传感器;（2）自动化机器人样品操作/制备装置;和（3）低能量，高通量，小型化机电系统与用户界面的数据集成和报告。 该项目将解决莱姆病病原体伯氏疏螺旋体的纳米传感检测，莱姆病是美国最流行的蜱传疾病。该项目的更广泛/商业影响将是提供用于病媒和疾病管理、国土安全、卫生保健、农业环境应用和食品安全市场中的生物检测的设备的潜力。 人们认为，早期发现是预防流行病的最佳解决办法。 在莱姆病的情况下，目前对伯氏疏螺旋体的检测是缓慢的、昂贵的，并且需要持续的人为干预和实验室条件，导致在疾病或流行病变得广泛之前实际上仅检测到一小部分引入的病原体。 这一项目将有助于对莱姆病和其他病原体的存在进行有效的实地监测。 这些数据将通过无线传输到一个中央枢纽，为决策者提供现场情况的实时情报，并为预防而不是危机控制行动留出时间。