SBIR Phase II: Sensory System for Autonomous Area-Wide Disease and Agriterror Detection and Reporting

SBIR 第二阶段：自治区范围内疾病和农业错误检测和报告的传感系统

• 批准号: 0725388
• 负责人: Agenor Mafra-Neto
• 金额: $ 50万
• 依托单位: ISCA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0725388&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Sensory; System

This SBIR Phase II research project will fabricate nanosensory arrays using the Micro-Electro-Mechanical Systems (MEMS) technique. This electrochemical polymerization of biomolecule-friendly conducting polymers was developed and successfully tested to build functional, highly reliable nanosensors. This research will address key technical challenges in automating the fabrication of antibody-functionalized conducting nanowires that are individually addressable and scalable to high-density biosensor arrays for the detection of Huanglongbing (HLB). The resultant nanosensory-arrays will form the base for the development of small, effective, inexpensive, field worthy, autonomous and automated pathogen detection devices. These units will permit the unattended processing of a large number of field samples, thus increasing the temporal and geographical density of data collection, providing superior pathogen and agri-terror detection.Current disease management techniques typically lack the data collection technologies needed to avert epidemics; diagnostic instruments are not amenable to unattended autonomous operation. Devices currently used are slow, expensive, bulky, and must interface with humans. Consequently, only few pathogen introductions are detected before causing widespread disease or epidemics. This research will increase the efficiency in detection of plant pathogens and agents of disease, allowing for preventative rather than crisis or remedial control actions. The development of this automated system can mitigate the estimated $300 billion loss due to agricultural pests.

SBIR第二阶段研究项目将使用微机电系统（MEMS）技术制造纳米传感器阵列。这种生物分子友好的导电聚合物的电化学聚合被开发并成功测试，以构建功能性的，高度可靠的纳米传感器。该研究将解决抗体功能化导电纳米线自动化制造的关键技术挑战，这些纳米线可单独寻址并可扩展到用于检测黄龙病（HLB）的高密度生物传感器阵列。由此产生的纳米传感器阵列将形成小型，有效，廉价，现场价值，自主和自动化的病原体检测设备的发展的基础。这些设备将允许无人值守地处理大量实地样本，从而增加数据收集的时间和地理密度，提供上级病原体和农业恐怖检测，目前的疾病管理技术通常缺乏避免流行病所需的数据收集技术;诊断仪器不适合无人值守的自主操作。目前使用的设备速度慢、价格昂贵、体积庞大，并且必须与人类交互。因此，在引起广泛的疾病或流行病之前，只有很少的病原体引入被检测到。这项研究将提高检测植物病原体和病原体的效率，从而采取预防性而不是危机或补救性控制行动。这一自动化系统的开发可以减轻农业害虫造成的估计3000亿美元的损失。