Embryonic regulation of the endocrine environment via the sulfotransferase-sulfatase pathway in an oviparous vertebrate
卵生脊椎动物通过磺基转移酶-硫酸酯酶途径对内分泌环境的胚胎调节
基本信息
- 批准号:0952840
- 负责人:
- 金额:$ 29.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-01 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Endocrine signaling during embryonic development regulates many physiological processes and can produce long-term effects that may persist throughout the lifetime of an organism. For example, the embryo may be exposed to steroid hormones produced by the mother. In mammals, including humans, the placenta produces enzymes that metabolize, and render inactive, maternal steroids before they reach the developing embryo. Thus, the embryo is buffered from the potentially detrimental effects of maternal steroids. In species that lay eggs, embryos are exposed to maternal steroids present in the yolk when the egg is laid. This project examines how maternal steroids move from the yolk to the embryo in turtles. In addition, a variety of molecular and biochemical techniques will be employed to characterize how these maternal steroids are metabolized during embryonic development. The proposed research will enhance our understanding of how embryos regulate their endocrine environment. Importantly, many of the same metabolic enzymes examined in this proposal are also responsible for metabolizing exogenous chemicals such as plasticizers and pesticides. Characterizing these enzymes will enable researchers to investigate whether these foreign chemicals may disrupt steroid metabolism to produce detrimental effects. Compared to those from live-bearing species, embryos from egg-laying species provide a powerful system in which to study how various factors influence embryonic steroid metabolism because they develop outside of the maternal environment and can be readily manipulated. All experiments in this proposal will provide training opportunities to both graduate and undergraduate students, as well as a post-doctoral researcher.
胚胎发育过程中的内分泌信号调节许多生理过程,并可产生可能持续整个生物体一生的长期影响。例如,胚胎可能会接触到母亲产生的类固醇激素。在包括人类在内的哺乳动物中,胎盘产生的酶在母体类固醇到达发育中的胚胎之前代谢并使其失去活性。因此,胚胎可以免受母体类固醇的潜在有害影响。在产卵的物种中,当产卵时,胚胎暴露在蛋黄中的母体类固醇中。这个项目研究了母体类固醇是如何从海龟的卵黄转移到胚胎的。此外,还将使用各种分子和生化技术来表征这些母体类固醇在胚胎发育期间如何代谢。这项拟议的研究将加深我们对胚胎如何调节其内分泌环境的理解。重要的是,该提案中研究的许多相同的代谢酶也负责代谢外源化学物质,如增塑剂和杀虫剂。对这些酶进行表征将使研究人员能够调查这些外来化学物质是否会扰乱类固醇新陈代谢,从而产生有害影响。与活的生育物种的胚胎相比,产卵物种的胚胎提供了一个强大的系统来研究各种因素是如何影响胚胎类固醇代谢的,因为它们在母体环境之外发育,并且很容易被操纵。该提案中的所有实验都将为研究生和本科生以及博士后研究员提供培训机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rachel Bowden其他文献
Teacher Research in the English Language Teacher Development Project
英语教师发展项目中的教师研究
- DOI:
10.1057/9781137376220_12 - 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Rachel Bowden - 通讯作者:
Rachel Bowden
Fantasy Higher Education: University and college league tables
- DOI:
10.1080/13538320050001063 - 发表时间:
2000-04 - 期刊:
- 影响因子:1.4
- 作者:
Rachel Bowden - 通讯作者:
Rachel Bowden
Professional Doctorates in England
英国专业博士学位
- DOI:
10.1080/03075070124819 - 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
T. Bourner;Rachel Bowden;Stuart Laing - 通讯作者:
Stuart Laing
Learner-centred education and English medium instruction: policies in practice in a lower-secondary mathematics class in rural Rwanda
以学习者为中心的教育和英语授课:卢旺达农村初中数学课堂的实践政策
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:1.8
- 作者:
Rachel Bowden;Innocente Uwineza;J. Dushimimana;Alphonse Uworwabayeho - 通讯作者:
Alphonse Uworwabayeho
Early years postgraduate surgical training programmes in the UK are failing to meet national quality standards: An analysis from the ASiT/BOTA Lost Tribe prospective cohort study of 2,569 surgical trainees.
英国早期的研究生外科培训项目未能达到国家质量标准:ASiT/BOTA Lost Tribe 前瞻性队列研究对 2,569 名外科学员进行的分析。
- DOI:
10.1016/j.ijsu.2017.09.074 - 发表时间:
2018 - 期刊:
- 影响因子:15.3
- 作者:
J. Glasbey;R. Harries;A. Beamish;V. Gokani;H. Mohan;Adam P Williams;Simon Fleming;Aaron Chai;Abhinav Singh;A. Stoneham;A. Lunt;Adeeb H. Rehman;A. Dhahri;A. Yvon;A. Dutta;A. Abou;A. Abdelrahman;A. Daoub;A. Sanalla;A. D. G. Rico;Alastair Konarski;A. Ward;Alexis Wilkin;Alexandra K. Winter;A. Arnaout;A. Bakhsh;A. Esfandiari;Alistair W. Hardy;A. Khan;A. Thacoor;A. Gavrila;Anca;Andreas Fontalis;A. Hall;A. Williamson;A. Kosti;A. Harlinska;A. Adimonye;A. Egglestone;A. Thaventhiran;A. Myatt;A. Vusirikala;A. Rawashdeh;Arjun C. Paramasivan;A. Cotton;A. Scrimshire;A. Ramesh;A. Krishnamoorthy;Asif Ahmed;Ayeshah Abdul;Ayushah Khan;B. Oremule;B. Ho;B. Barkham;B. Collard;B. Edgar;B. Drake;Bethan John;C. R. Gordon;C. Rossborough;Chang Park;C. Seretis;C. H. Johnson;C. Gill;C. Serino;C. Ogbuokiri;C. Swords;C. Kang;Chris McKinnon;Christopher E. Brown;C. J. Manning;C. Marusza;Christopher P Jones;C. Forde;Claire L. Wilson;C. Koh;Conal Horgan;Daniel J. Lin;D. Ashmore;D. Ness;Daniel O. Akhtar;D. Doherty;D. Scholfield;D. Ensor;D. Bratt;David J. Spence;D. Thomson;D. Ferguson;D. Apparau;Devaraj M. Navaratnam;D. Mai;D. Rutherford;E. Karam;E. Wu;E. Zimmermann;E. Douka;E. Flatt;E. Kane;Elizabeth L. Thornhill;E. Gammeri;E. Littlehales;E. M. Valsamis;E. Hankin;E. Meenan;Etienne Botha;F. Khalid;Fatema Patel;F. Power;Fiona Rutherford;Fozia Saeed;Francesca L. Guest;Francisco J. Barbosa;F. Cameron;Furqan R. Raja;G. Thiruchandran;G. Munbauhal;G. Dovey;G. E. Hogg;G. Dovell;G. Matheron;G. T. Hill;G. Layton;Georgiana G.S. Jong;G. Hicks;G. Millward;Grahame Shaw;G. Stamp;H. Parwaiz;H. H. Chong;H. Copley;Hannah Lennox;Hannah M. Emerson;H. F. Dean;H. Eltyeb;H. Chu;I. Sadien;Imran Mohamed;I. Parwaiz;Isabella Drummond;J. Pearce;J. Ahmed;J. Koris;J. Rait;James Bailey;J. A. Cohen;James A. Kennedy;J. Olivier;James Bailey;James E. Archer;James J. Stewart;James Barros;James R. Allen;J. W. O'Brien;James;T. McGhee;Jared Quarcoopome;J. Winyard;J. Roberts;J. Barwell;Jeremy Rodrigues;J. Chapman;J. Fairbanks;J. Voll;J. Lim;Jinlai Chang;J. Bovis;J. Ferns;J. Tam;J. Herron;J. Macdonald;J. Ducey;Joseph W. Dixon;Joshua T. Luck;K. Hewage;K. Yakoub;K. Bhopal;K. Vejsbjerg;K. Aboelmagd;K. Bera;K. Hamlett;Katherine E. Fok;K. Hurst;K. Gillams;Katie L. Siggens;K. Young;Ken Burns;K. Burke;K. Seebah;Khalid Shah;Kieran Bentick;Kiran Majid;Kirsty L. Davies;K;K. Baryeh;L. Phillips;L. Ellerton;Leeying Giet;L. Monaghan;L. Cheung;Louise L. Shen;L. Paramore;L. Arrowsmith;L. Attwell;Luke Thornton;L. Xu;M. Leadon;M. Natarajan;M. Houlihan;Marisa Cheah;M. Sagmeister;Maryam O Abubakar;Matthew F. Flynn;M. Harris;M. Stone;M. Young;M. Gray;M. Horner;M. Schembri;M. Trail;M. Joy;M. Rice;Michael P. Thomas;M. Poon;M. Stoddart;M. L. Fong;Mitchell T. Foster;M. Mohamud;M. N. Hoque;M. Remtulla;Mohsin Javed Karim;M. Řezáčová;M. B. Siddiqui;M. Iqbal;M. Mensa;N. McCauley;N. Bauer;N. Walker;N. A. Hakim;Ngonidzashe Knight;N. O'Hara;Nicholas A. Fawcett;N. Wong;Nicola F.D. Allen;N. Husnoo;N. Vallabh;N. Srikandarajah;Nnaemeka Chidumije;O. Elamin;Odunayo Akinlaja;O. Griffiths;Oliver D Brown;O. Shastri;Olivia J. Cameron;Olivia Kenyon;O. Javed;O. Sogaolu;P. Birmpili;P. Haylock;P. Green;P. Carroll;Peiming Yang;P. Beak;Pia Persson;P. J. Tam;Rabia Waqar;R. Morley;Rachel Bowden;Rachel L. Eyre;R. Pankhania;R. Sahemey;R. Kabariti;M. Rawashdeh;Rawashdeh S. Arab;R. Rollett;R. Nicholas;R. Morgan;R. Limb;R. Robinson;Richard S Hayes;R. Daureeawoo;R. A. Cooke;R. Espey;R. Chessman;R. Whitham;R. E. Payne;R. Staruch;R. Alho;R. Gordon;R. Cuthbert;Roseanna B. Harrison;R. Scott;R. M. Parks;R. Cheong;Ryan Hillier;Ryan Moffatt;Saad Rehman;Sabah Ambren;S. Abdulal;S. Kulkarni;S. Hopwood;S. Greenfield;S. Mehta;S. Haines;S. Alsaati;S. Williams;S. El;S. Barlow;S. Pywell;S. Pollock;S. Lampridis;S. Nazarian;S. Rezvani;S. Scattergood;S. Toescu;S. Hotonu;S. Shaikh;S. Rupani;Shumaila Hasan;S. Pradeep;S. Cole;S. Growcott;Sofia E. Bedoya;S. Ike;S. Bodnarescu;S. C. Seppings;S. A. Poyntz;S. Jordan;Sundas Iqbal;Suparna Das;S. Chatterjee;S. Shumon;Tamsin E. M. Morrison;T. Sibartie;T. Aboelmagd;Thomas B. Russell;Thomas Seddon;T. Stringfellow;T. Goldsmith;Thomas H. Banks;T. Tolley;T. Oputa;T. Kanzara;T. Challoner;T. Urbonas;T. Richards;V. Morrison;Vivek Garikapati;Waheeb Al;Wajiha Zahra;W. Ho;W. Al;W. Gibson;Yasmin Grant;Y. Hijazi;Yayganeh Chiang;Z. Gundkalli;Zoe M. Seymour;Z. Panayi - 通讯作者:
Z. Panayi
Rachel Bowden的其他文献
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{{ truncateString('Rachel Bowden', 18)}}的其他基金
Responsiveness of sex determination to thermal cues and maternal estrogens as potential modifiers
性别决定对热线索和母体雌激素作为潜在调节剂的反应
- 批准号:
2114111 - 财政年份:2021
- 资助金额:
$ 29.25万 - 项目类别:
Continuing Grant
Endocrine-Immune Interactions: Estrogens as Immunomodulators
内分泌免疫相互作用:雌激素作为免疫调节剂
- 批准号:
0748505 - 财政年份:2008
- 资助金额:
$ 29.25万 - 项目类别:
Standard Grant
CONFERENCE- CONSEQUENCES OF MATERNALLY DERIVED YOLK HORMONES FOR OFFSPRING PHENOTYPE: CURRENT STATUS, CHALLENGES, AND OPPORTUNITIES, TO BE HELD JANUARY 2-6,2008 IN SAN ANTONIO, TX.
会议——母体卵黄激素对后代表型的影响:现状、挑战和机遇,将于 2008 年 1 月 2-6 日在德克萨斯州圣安东尼奥举行。
- 批准号:
0737608 - 财政年份:2007
- 资助金额:
$ 29.25万 - 项目类别:
Standard Grant
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