Environmentally Friendly Organophosphorus Chemistry

本项目将继续发展磷碳成键反应。提出了基于次磷酸及其衍生物和h -膦酸盐的新型催化反应，以提供原子经济的过程。具体来说，这些努力包括a)过渡金属催化下烷基膦酸盐的P-H活化，包括在首席研究员实验室发现的钯和镍催化的氢膦化的进一步发展；b) h -膦酸盐活化P-H；c)逐步淘汰有机磷化合物生产中的三氯化磷，从而通过催化制备和使用h -膦酸盐减少与氯使用相关的环境影响和能源需求。h -膦酸盐衍生物具有磷的中间氧化态，并且它们可以衍生成大量其他重要的官能团。这个奖项,化学合成的程序支持的研究教授让-吕克·Montchamp德州基督教大学化学系。蒙尚教授的研究工作围绕着在催化条件下形成P-C和P-O键的方法的发展。这种化学将有助于采用无害环境的方法来化学合成有机磷化合物，这在许多产品的制造中都很重要，如治疗剂、农用化学品和催化用磷化氢配体。

This project will continue the development of phosphorus-carbon bond-forming reactions. New catalytic reactions are proposed based on hypophosphorous acid and its derivatives, and on H-phosphinates to provide atom-economical processes. Specifically, these efforts involve a) P-H activation in alkyl phosphinates under transition-metal catalysis, including further developments of the palladium- and nickel-catalyzed hydrophosphinylations discovered in the principal investigator's laboratory; b) P-H activation in H-phosphinates; and c) phasing out phosphorus trichloride in the manufacturing of organophosphorus compounds, thereby reducing the environmental impact and energy-demand associated with chlorine usage through the catalytic preparation and use of H-phosphinates. H-Phosphinate derivatives possess an oxidation state in the middle of the range for phosphorus, and they can be derivatized into a plethora of other important functional groups.With this award, the Chemical Synthesis program is supporting the research of Professor Jean-Luc Montchamp of the Department of Chemistry at Texas Christian University. Professor Montchamp's research efforts revolve around the development of methodology for the formation of P-C and P-O bonds under catalytic conditions. Such chemistry will contribute to environmentally benign methods for the chemical synthesis of organophosphorus compounds, which are important in the manufacturing of many products, such as therapeutic agents, agrochemicals, and phosphine ligands for catalysis.