SYNTHESIS OF P-CHIRAL ORGANOPHOSPHORUS COMPOUNDS

在这个由化学系化学合成计划资助的项目中，德克萨斯基督教大学化学系的Jean-Luc MontChamp教授将探索开发在磷原子上形成手性化合物(P-手性有机磷化合物)的方法。获得P-手性化合物仍然是一个重大的合成挑战，化学家们在很大程度上仍然依赖于稀有的商业可得但昂贵的化合物来开发他们的各种催化方法。本方案旨在实现对手性膦化合物的通用性和实用化。虽然存在多种方法，但到目前为止，每一种方法都面临着成本高、范围和可扩展性有限、时间投资长或实验条件复杂等显著局限性。由于手性膦在不对称催化中普遍存在，因此合成对映体化合物的实际路线可能对不对称催化有很大的影响。更有效的对映选择性催化将在所有需要合成手性分子的化学领域产生影响，如制药、农业和化学工业。此外，该项目将为同事提供极好的培训，从本科生研究参与者到博士后，包括那些在自然科学领域历来代表性不足的人。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Jean-Luc Montchamp of the Department of Chemistry at Texas Christian University will explore the development of methods for the formation of compounds that are chiral at the phosphorus atom (P-chiral organophosphorus compounds). Access to P-chiral compounds remains a major synthetic challenge, and chemists largely still rely on rare commercially available but expensive compounds for the development of their various catalytic methodologies. This proposal aims at the general and practical preparation of P-chiral phosphorus compounds. Although a variety of methods exists, to date every single method suffers from significant limitations such as high cost, limited scope and scalability, extended time-investment, or complicated experimental conditions. Practical routes to P-chiral compounds could have a major impact on enantioselective catalysis, as chiral phosphines are ubiquitous in enantioselective catalysis. More effective enantioselective catalysis will have an impact in all areas of chemistry where the synthesis of chiral molecules is needed such as the pharmaceutical, agricultural, and chemical industries. Additionally, this project will provide excellent training of coworkers, from undergraduate research participants to post-doctoral, including those from groups historically underrepresented in the physical sciences.