CAREER: Iron mediated catalytic C-H bond functionalization

职业：铁介导的催化 C-H 键功能化

• 批准号: 0955885
• 负责人: Theodore Betley
• 金额: $ 60万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0955885&HistoricalAwards=false
• 关键词: CAREER; Iron; mediated; catalytic; bond

The Chemical Catalysis Program supports the efforts of Professor Theodore Betley of Harvard University on iron-mediated, catalytic carbon-hydrogen (C-H) bond functionalization. Professor Betley's group synthesizes electrophilic complexes featuring transiently-formed metal-ligand multiple bonds. These metal catalysts contain hard donor, weak-field dipyrromethane and tris(pyrrolyl)ethane ligand scaffolds that were selected for their ability to confer a wide range of steric and electronic environments to the first row-transition metal ion. Catalytic C-H bond amination reactions are being explored to determine the scope, activity, and mechanisms of the reaction.This award examines the activation of carbon-hydrogen bonds as a way of converting inexpensive chemical feedstocks (hydrocarbons) to valuable functional molecules with minimal waste generation. Importantly, Professor Betley and his group are using non-toxic and earth-abundant elements, such as iron, to perform these important transformations. The targeted products are useful in many fields, ranging from pharmaceutical production to value-added commodity chemicals for buildings and automobiles. This research effort is well-integrated into the classroom. Professor Betley organizes the Experience the Elements Firsthand, an interactive demonstration for students at the K-12 level from Boston's local grade schools and high schools. In this program, the students are invited to participate in a series of experiments and observe chemical phenomena in the laboratory. Professor Betley also co-directs an academic outreach program aimed at attracting traditionally underrepresented minority students in the chemical sciences and is active in Hawaii's federally-funded Upward-Bound program to promote interest in the sciences in first-generation students.

化学催化计划支持哈佛大学的西奥多·贝特利教授在铁介导的催化碳-氢(C-H)键功能化方面的努力。贝特利教授的团队合成了具有瞬时形成的金属-配体多键的亲电络合物。这些金属催化剂包含硬施主、弱场二吡咯甲烷和三(吡咯基)乙烷配体支架，因为它们能够为第一排过渡金属离子提供广泛的空间和电子环境。目前正在探索催化C-H键胺化反应，以确定反应的范围、活性和机理。该奖项考察了碳氢键的激活作为一种将廉价的化学原料(碳氢化合物)转化为有价值的功能分子的方法，产生的废物最少。重要的是，贝特利教授和他的团队正在使用无毒和富含地球的元素，如铁，来执行这些重要的转变。目标产品在许多领域都很有用，从药品生产到用于建筑和汽车的增值商品化学品。这项研究工作很好地融入了课堂。贝特利教授组织了元素第一手体验，为波士顿当地小学和高中的K-12年级学生提供了互动演示。在这个项目中，学生们被邀请参加一系列的实验，并在实验室里观察化学现象。贝特利教授还共同主持了一个学术推广计划，旨在吸引化学科学领域传统上代表性较低的少数族裔学生，并积极参与夏威夷联邦资助的向上发展计划，以促进第一代学生对科学的兴趣。