MRI: Acquisition of Single-Crystal Diffractometer for Small Molecule Crystallography and Cryosystem

MRI：获取用于小分子晶体学和冷冻系统的单晶衍射仪

• 批准号: 2216066
• 负责人: Theodore Betley
• 金额: $ 30.07万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216066&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; Diffractometer

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Harvard University is acquiring a dual-source single crystal diffractometer equipped with high-flux Cu and Mo microfocus X-ray sources, an enhanced detector, and a cryogenic device to support the research of Professor Theodore Betley and colleagues Jarad Mason, Daniel Nocera, and Shao-Liang Zheng. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, biochemistry, and catalysis. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution. The facility serves as a regional XRD resource benefitting students and faculty from primarily undergraduate institutions within the Commonwealth of Massachusetts and surround New England regions with impacts through active collaborations with researchers at Wellesley College.The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on organic synthesis, photoredox catalysis, C-H bond oxidation and functionalization catalysis, organocatalysis, reactive intermediate isolation, chemotherapeutic development, small molecule activation, novel magnetic material synthesis, tunable metal-organic phase- change materials, barocaloric responsive materials, and porous network materials. Furthermore, the new diffractometer will be utilized in probing both photo excited state and thermally driven transformation during in situ diffraction collection.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目联合支持。哈佛大学正在购买一个配备高通量Cu和Mo微聚焦x射线源的双源单晶衍射仪、一个增强型探测器和一个低温设备，以支持Theodore Betley教授及其同事Jarad Mason、Daniel Nocera和郑少亮的研究。一般来说，x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响许多领域，包括有机和无机化学，材料化学，生物化学和催化。该仪器是该机构化学和生物化学本科生和研究生的教学、研究和研究训练的一个组成部分。该设施作为区域XRD资源，通过与韦尔斯利学院的研究人员积极合作，使马萨诸塞州联邦内主要本科院校的学生和教师受益，并影响新英格兰地区。该奖项旨在加强各级的研究和教育。该仪器的研究领域包括有机合成、光氧化还原催化、C-H键氧化和功能化催化、有机催化、反应中间体分离、化学疗法开发、小分子活化、新型磁性材料合成、可调谐金属-有机相变材料、高压响应材料和多孔网络材料。此外，新的衍射仪将用于探测原位衍射收集过程中的光激发态和热驱动转变。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。