Position sensitive investigation of the lithium concentration in the human brain

人脑中锂浓度的位置敏感研究

• 批准号: 195705552
• 负责人: Dr. Roman Gernhäuser
• 金额: --
• 依托单位: Arbeitsgruppe Dichte und seltsame hadronische Materie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/195705552?language=en
• 关键词: Position; sensitive; investigation; lithium; concentration

We propose a project to further develop and apply a new method for the ultra sensitive detection of lithium traces in human tissue for a deeper understanding of the lithium methabolism and its influence on the mental human diseases. Lithium carbonate salt has become an increasingly important sub-stance in the treatment of manic depressive disorders and lithium is used already for several decades as it is very efficient in the equilibration of mood cycles. Nonetheless there is currently no consistent detailed picture how it acts inside the human brain. In the framework of a just completed diploma the-sis we developed a new technique for position sensitive detection of lithium traces in human tissue samples on the basis of the 6Li(n,α)t reaction. Using detectors for the coincident detection of α and t in a very compact setup at the FRM II neutron source we demonstrated a significance level of 3 ppb for position sensitive (Δx < 200 μm) lithium detection in untreated organic samples. Within the proposed project we plan to improve the existing setup to achieve a factor of 30 higher sensitivity while reducing the measurement time from several hours to a few minutes. This will allow for first time to collect a high resolution map of lithium distributions in the human brain on a microscopic (200 μm) and a ma-croscopic (different functional areas) scale. All measurements will be performed in close collaboration with the Institut für Rechtsmedizin München and the Münchner Neutronenquelle FRM II.

我们提出了一个项目，以进一步开发和应用一种新的方法，用于超灵敏检测人体组织中的微量锂，以更深入地了解锂蛋氨酸及其对精神人类疾病的影响。碳酸锂盐已成为治疗躁狂抑郁症的越来越重要的物质，并且锂已经使用了几十年，因为它在平衡情绪周期方面非常有效。尽管如此，目前还没有一致的详细图片，它是如何在人类大脑中发挥作用的。在刚刚完成的学位论文的框架下，我们开发了一种基于6Li（n，α）t反应的人体组织样品中痕量锂的位置灵敏检测新技术。在FRM II中子源的一个非常紧凑的装置中使用探测器同时探测α和t，我们证明了在未处理的有机样品中位置灵敏（Δx < 200 μm）锂探测的显著性水平为3 ppb。在拟议的项目中，我们计划改进现有的设置，以实现30倍的灵敏度，同时将测量时间从几个小时减少到几分钟。这将首次在显微镜（200 μm）和宏观（不同功能区域）尺度上收集人脑中锂分布的高分辨率地图。所有测量都将与慕尼黑法律医学研究所和慕尼黑Neutronenquelle FRM II密切合作。