Bone Tissue: Multi-Scale Simulation for Clinical Applications; Los Angeles, CA; April 19-23, 2010.

ID：MPS/DMR/BMAT(7623)0964022 PI：Ascenzi，Maria-Grazia ORG：UCLATitle：骨组织：临床应用的多尺度模拟INTELLECTUAL优点：召集工程师、数学家、系统生物学家、临床研究人员和临床医生制定一项计划，以开发能够解决特定临床问题的骨组织的3D多尺度虚拟渲染。拟议的研讨会将是一个新的机会，让研究人员和临床医生，包括初级同事，按照机构间建模和分析小组(IMAG)的目标和美国国立卫生研究院(NIH)路线图的路线，接触不同但兼容的专业知识，以设计一个共同的行动计划，以开发最先进的3D多尺度骨骼模型。拟议的为期三天的研讨会形式将允许来自不同领域的专家相互教授有关骨骼建模的最新发展，并设计合作计划以解决具有挑战性的问题。每天将从系统生物学家、数学家和工程师介绍临床问题和相关技术开始。在讲习班的头两个下午，圆桌会议将讨论特定天的临床问题，旨在设计一项计划，以获得必要的额外实验数据，并调整现有的数学和工程工具，以准备适当的多尺度模型。研讨会的最后一个下午将专门审查研究规划和合作，以确保每个人都知道他/她正在发挥的具体作用和贡献。随着研讨会的结束，每个参与者都将认识到他/她在推进针对所检查的每个临床问题的骨组织的3D多尺度建模方面所起的作用。更广泛的影响：拟议的研讨会将：(1)建立跨学科、机构和资历的关键新网络和伙伴关系的基础；(2)通过鼓励参加研讨会，为进一步提高妇女和少数群体的地位创造机会；(3)为补充学科的初级和高级研究人员提供培训；(4)改善与骨骼相关的疾病的治疗和公共卫生管理；以及(5)可能为基于对骨骼作为一种天然复合材料-混合材料的更深层次理解而制定新材料提供见解。

ID: MPS/DMR/BMAT(7623) 0964022 PI: Ascenzi, Maria-Grazia ORG: UCLATitle: Bone Tissue: Multi-scale Simulation for Clinical ApplicationsINTELLECTUAL MERIT: Engineers, mathematicians, system biologists, clinical researchers, andclinicians are convened to formulate a plan to develop 3D multi-scale virtual rendering of bonetissue able to address specific clinical issues. The proposed workshop will be a novel opportunity to expose researchers and clinicians, including junior colleagues, to diverse, but compatible expertise, along the lines of the Interagency Modeling and Analysis Group (IMAG) aim and the National Institutes of Health (NIH) Roadmap, to design a common plan of action to develop state-of-the-art 3D multi-scale models of bone. The proposed three-day workshop format will allow experts from different fields to teach each other the latest developments concerning bone modeling and to design collaborative plans to solve challenging problems. Each day will begin with presentation of clinical problems and relevant technologies by systems biologists, mathematicians, and engineers. During the first two afternoons of the workshop, round-tables will address day-specific clinical problems, aiming to design a plan to obtain necessary additional experimental data and to adapt existing mathematical and engineering tools for preparation of the appropriate multi-scale model. The last afternoon of the workshop will be dedicated to reviewing the research planning and collaborations to make sure that each person knows his/her particular ongoing role and contribution. As the workshop closes, each participant will appreciate his/her role in advancing the 3D multi-scale modeling of the bone tissue for each of the clinical problems examined. BROADER IMPACTS: The proposed workshop will (1) establish the bases for critical new networks and partnerships across disciplines, institutions, and seniority, (2) create opportunities for further advancement of women and minorities through encouragement to participate in the workshop, (3) provide training for junior and senior researchers in complementary disciplines, (4) improve treatment and public health management of bone related conditions; and (5) potentially provide insights for the formulation of new materials based on deeper understanding of bone as a natural composite-hybrid material.