RUI: Diffusion of Cyclodexrtrins and Cyclodextrin Polymeric Nanoparticles in Mucus Studied by 19F Diffusion NMR

在这个由化学系化学结构、动力学和机制计划支持的项目中，洛杉矶加州州立大学的巴勇教授将利用核磁共振技术来探索大分子和聚合物纳米颗粒在接近生物粘液介质的粘性液体中的扩散。核磁共振扩散研究将集中在粘液模型中被不同环糊精包裹的氟化金刚烷。氟化金刚烷将通过核磁共振活性19F核进行探测，扩散参数将使用脉冲场梯度技术提取。这项研究还将涉及环糊精衍生物的合成；对这些衍生物的表征将需要质谱学、质子核磁共振和光散射技术。环糊精具有潜在的药物传递载体，因此了解其在类似鼻腔或胃肠膜的材料中的扩散特性是可取的。国际学生联合会将在很大程度上依赖学生对研究的贡献，这些学生来自CSULA人数较少的少数族裔群体。参与这项研究的学生将有机会接触到现代核磁共振设备，在那里他们不仅将被介绍专门的扩散技术，而且还将被介绍传统的一维和二维核磁共振实验。

In this project supported by the Chemical Structure, Dynamics and Mechanisms Program of the Division of Chemistry, Professor Yong Ba of the California State University at Los Angeles will employ nuclear magnetic resonance (NMR) techniques to explore the diffusion of large molecules and polymeric nanoparticles in viscous liquids approximating biological mucus media. NMR diffusion studies will focus on fluorinated adamantane enclosed in different cyclodextrins in mucus models. The fluorinated adamantane will enable the exploration via the NMR active 19F nucleus, and diffusion parameters will be extracted using pulsed-field gradient techniques. The research will also involve the synthesis of cyclodextrin derivatives; characterization of these will entail mass spectrometric, proton NMR, and light scattering techniques. Cyclodextrin has potential as drug delivery vehicle, and an understanding of its diffusion properties across materials resembling nasal or gastrointestinal membranes is thus desirable. The PI will heavily rely on student contributions to research from the large pool of students from underrepresented minority groups at CSULA. Students involved in this research will have access to a modern NMR facility, where they will be introduced not only to specialized diffusion techniques, but conventional 1D and 2D NMR experiments as well.