Novel Platinum and Palladium Reactions Relevant to Hydrocarbon Functionalization

在这个由化学系化学催化计划资助的项目中，华盛顿大学的Karen I.Goldberg教授将从机理上详细了解基本的有机金属反应，这些反应可以选择性地裂解碳-氢键，可以激活分子氧以使其能够用作选择性氧化剂，并且可以通过形成新的碳-碳和碳-氧键来选择性地生产功能化有机产品。这些反应对于研究和理解是至关重要的，因为它们可以应用于我们社会必不可少的化学品和材料的制造--从塑料和建筑用品，到新的农产品和药品。这些化学品中的许多都是大规模生产的。但目前的过程很复杂，消耗大量能源和/或产生大量废物。戈德伯格教授的努力可能会使化学家能够更快、更有选择性地进行反应，使用更少的能源，使用更少的危险试剂，并产生更少的副产品。更广泛的影响涉及到与高中生、教师和普通公众的接触，以及对本科生和研究生研究人员的培训。这项工作将增强我们对催化过程的基本理解。从以石油为基础的产品中生产散装化学品的更有效的方法是非常有必要的。此外，能够激活和选择性地转化烷烃中的C-H键，通过提供有效运输和利用天然气储备的新途径，可以显著影响我们对石油的依赖。

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Karen I. Goldberg of the University of Washington will develop detailed mechanistic understanding of fundamental organometallic reactions that can selectively cleave carbon-hydrogen bonds, can activate molecular oxygen to enable its use as a selective oxidant, and can selectively produce functionalized organic products through the formation of new carbon-carbon and carbon-oxygen bonds. These reactions are vital to study and understand because they can be applied to the manufacturing of chemicals and materials that are essential to our society - from plastics and building supplies, to new agricultural products and pharmaceuticals. Many of these chemicals are produced on huge scales. But the current processes are complex, consume large amounts of energy and/or produce significant waste. Professor Goldberg's efforts may enable chemists to conduct the reactions more quickly and selectively using less energy, using less dangerous reagents, and producing fewer by-products. The broader impacts involve outreach to high school students, teachers, and the general public as well as training of undergraduate and graduate student researchers.This work will enhance our fundamental understanding about catalytic processes. There is a substantial need for more efficient ways of making bulk chemicals from petroleum-based products. In addition, being able to activate and selectively transform C-H bonds in alkanes could significantly impact our dependence on oil by providing new routes to efficiently transport and utilize natural gas reserves.