Novel Platinum and Palladium Reactions Relevant to Hydrocarbon Functionalization

与碳氢化合物官能化相关的新型铂和钯反应

• 批准号: 1012045
• 负责人: Karen Goldberg
• 金额: $ 48.48万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012045&HistoricalAwards=false
• 关键词: Novel; Platinum; Palladium; Reactions; Relevant

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Karen I. Goldberg of the University of Washington will develop detailed mechanistic understanding of fundamental organometallic reactions that can selectively cleave carbon-hydrogen bonds, can activate molecular oxygen to enable its use as a selective oxidant, and can selectively produce functionalized organic products through the formation of new carbon-carbon and carbon-oxygen bonds. These reactions are vital to study and understand because they can be applied to the manufacturing of chemicals and materials that are essential to our society - from plastics and building supplies, to new agricultural products and pharmaceuticals. Many of these chemicals are produced on huge scales. But the current processes are complex, consume large amounts of energy and/or produce significant waste. Professor Goldberg's efforts may enable chemists to conduct the reactions more quickly and selectively using less energy, using less dangerous reagents, and producing fewer by-products. The broader impacts involve outreach to high school students, teachers, and the general public as well as training of undergraduate and graduate student researchers.This work will enhance our fundamental understanding about catalytic processes. There is a substantial need for more efficient ways of making bulk chemicals from petroleum-based products. In addition, being able to activate and selectively transform C-H bonds in alkanes could significantly impact our dependence on oil by providing new routes to efficiently transport and utilize natural gas reserves.

在这个由化学系化学催化项目资助的项目中，凯伦教授。华盛顿大学的Goldberg将发展对基本有机金属反应的详细机理理解，这些反应可以选择性地裂解碳-氢键，可以活化分子氧以使其能够用作选择性氧化剂，并且可以通过形成新的碳-碳和碳-氧键来选择性地生产功能化的有机产品。这些反应对于研究和理解至关重要，因为它们可以应用于制造对我们社会至关重要的化学品和材料-从塑料和建筑用品到新的农产品和药品。这些化学品中有许多是大规模生产的。但是目前的方法是复杂的，消耗大量的能量和/或产生大量的废物。戈德堡教授的努力可能使化学家能够更快地进行反应，并选择性地使用更少的能源，使用更少的危险试剂，并产生更少的副产品。更广泛的影响包括对高中生、教师和公众的宣传以及对本科生和研究生研究人员的培训。这项工作将增强我们对催化过程的基本理解。存在对从石油基产品制造散装化学品的更有效的方法的实质性需要。 此外，能够激活和选择性地转化烷烃中的C-H键，可以通过提供有效运输和利用天然气储量的新途径，显著影响我们对石油的依赖。