Fundamental Reactions Relevant to Selective Hydrocarbon Functionalization with Late-Transition Metals

有了这个奖项，化学系的化学催化计划资助教授卡伦我。戈德堡的研究，旨在提高对设计催化剂所需的关键反应的一般机理理解，这些催化剂能够实现高效节能、环保且具有成本效益的碳氢化合物转化。华盛顿大学的戈德堡。选择性转化碳氢化合物的碳氢键以产生更高价值产品的新催化方法有可能影响大规模化学生产。 新工艺最终可能允许工业化学家通过使用可用的和未被重视的碳原料以及生产中丰富的无毒试剂来实现更可持续的工艺。 在该项目中，正在仔细研究碳氢化合物官能化中所涉及的特定反应步骤的机制，例如碳氢键断裂和从空气中引入氧气，以实现其在选择性催化中的最佳应用。一组不同的研究生和本科生正在接受现代方法的培训，以研究催化和机理。 鼓励学生追求科学事业，强调需要一支强大的有效独立科学家队伍。 计划向高中生和公众宣传催化研究在寻找新的能源效率和环境友好的方法中的重要作用，这些方法用于制造许多日常产品，从塑料，油漆到药品。Goldberg教授正在发展对基本有机金属反应的详细机械理解，并在碳氢化合物的碳-氢键的官能化中具有潜在的应用，包括选择性甲烷氧化。正在研究用于活化碳-氢键、用于选择性活化和将氧并入金属-烷基键以及用于区域选择性烯烃加氢芳基化转化的新策略。 正在研究关键的模型反应，并通过调查这些化学计量和催化反应，促进这些转变的关键变量正在确定。 有关具体的协调环境，金属和配体的选择，基板的要求和反应条件，有利于特定的反应步骤的见解设想。 从这些研究中收集到的机械信息可能对学术和工业环境中的催化研究产生明显更广泛的影响。

With this award, the Chemical Catalysis Program of the Division of Chemistry is funding Professor Karen I. Goldberg of the University of Washington to improve the general mechanistic understanding of key reactions needed to design catalysts that enable an energy efficient, environmentally benign and cost-effective transformation of hydrocarbons. New catalytic methods that selectively convert the carbon-hydrogen bonds of hydrocarbons to yield higher value products have the potential to impact large-scale chemical production. New processes may eventually permit industrial chemists to achieve more sustainable processes by employing available and underappreciated carbon feedstocks, and abundant, non-toxic reagents in production. Within this project, the mechanisms of specific reaction steps involved in hydrocarbon functionalization, such as carbon-hydrogen bond cleavage and incorporation of oxygen from air, are being carefully investigated for their optimal application in selective catalysis. A diverse group of graduate and undergraduate students is being trained in modern methods for studying catalysis and mechanism. Students are encouraged to pursue careers in science, with emphasis on the need for a strong workforce of effective independent scientists. Outreach to high school students and the general public is being planned to communicate the vital role of catalysis research in finding new energy efficient and environmentally benign methods for making many everyday products from plastics, to paints, to pharmaceuticals.Professor Goldberg is developing a detailed mechanistic understanding of fundamental organometallic reactions with potential applications in the functionalization of carbon-hydrogen bonds of hydrocarbons, including selective methane oxidation. New strategies for activating carbon-hydrogen bonds, for selectively activating and incorporating oxygen into metal-alkyl bonds, and for regioselective olefin hydroarylation transformations are being investigated. Key model reactions are being studied, and through investigations of these stoichiometric and catalytic reactions, critical variables for promoting these transformations are being determined. Insights concerning specific coordination environments, metal and ligand options, substrate requirements and reaction conditions that favor particular reaction steps are envisaged. The mechanistic information gleaned from these studies may have a distinctly broader impact on catalysis research, in both academic and industrial settings.