Collaborative Research: New Ratiometric Fluorescent Indicators for Copper

合作研究：铜的新型比率荧光指示剂

• 批准号: 1012905
• 负责人: Shawn Burdette
• 金额: $ 12万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012905&HistoricalAwards=false
• 关键词: Collaborative; Research; New; Ratiometric; Fluorescent

With support from the Chemical Measurement and Imaging Program, and co-funding from the Experimental Program to Stimulate Competitive Research, Profs. Rudolf Seitz and Roy Planalp from the University of New Hampshire, in collaboration with Prof. Shawn Burdette from the University of Connecticut, are developing and characterizing a new approach to preparing co-polymer based ratiometric fluorimetric indicators for metal ions. The approach separates complexation from fluorescence, thereby allowing preparation of ratiometric indicators for important metal ions like Cu(II), Pb(II), Fe(III), etc., which normally quench fluorescence. This project will provide a new approach to measuring levels of toxic metals in municipal waters and will have a rapid and positive impact on public safety because of an established relationship with Envirosystems, Inc., a Womens Business Enterprise-certified company that can rapidly develop laboratory research for practical applications. The project will involve participants and trainees at many levels including high school, undergraduate, graduate, and postdoctoral, and will involve underrepresented groups and women. New students beginning on this project will be assigned a senior graduate student or postdoctoral mentor, who will share mentoring duties with the PI.

在化学测量和成像计划的支持下，以及实验计划的共同资助下，以刺激竞争性研究，教授说。新汉普郡大学的鲁道夫·塞茨和罗伊·普拉纳普与康涅狄格大学的肖恩·伯德特教授合作，正在开发并表征一种新的方法，以制备基于共聚物的金属离子比率荧光指示剂。该方法将络合与荧光分离，从而允许制备铜(II)、铅(II)、铁(III)等重要金属离子的比率指示剂，这些离子通常会猝灭荧光。该项目将提供一种测量市政水中有毒金属水平的新方法，并将对公共安全产生迅速和积极的影响，因为该项目与环境系统公司建立了合作关系，环境系统公司是一家获得妇女商业企业认证的公司，可以为实际应用快速开发实验室研究。该项目将涉及多个层次的参与者和受训人员，包括高中、本科生、研究生和博士后，并将涉及代表性不足的群体和妇女。开始这个项目的新生将被分配一名高级研究生或博士后导师，他们将与PI分担指导职责。