International Collaboration in Chemistry: Green Chemistry for Catalytic C-C Coupling of Renewable Feedstocks

化学系的化学催化项目支持美国德克萨斯大学奥斯汀分校的Michael J. Krische教授。 国际合作者，德国Albert-Ludwigs-Universität的Bernhard Breit教授得到了德国资助机构DFG的支持，该合作将设计商品和精细化学品的新路线。该奖项是根据NSF 09-608计划公告：美国研究人员与国外同行之间的化学国际合作（ICC）提交的。研究人员建议开发催化工艺，使化学产品的副产品从丰富的，可再生资源的生产。Breit集团将设计和制备一系列新型膦配体，其中包含专门为活化羰基（包括二氧化碳）而定制的超分子识别元素。这些“第一代金属络合物”将在Krische集团开发的C-C键形成氢化反应中进行分析，以确定关键的结构反应性和结构选择性趋势，这将使Krische和Breit能够设计改进的第二代催化剂，这些催化剂将由Breit集团制备并由Krische集团进行分析。Krische和Breit小组之间的合作是科学专业知识的理想结合，将通过直接接触大西洋两岸的研究技术，方法，哲学和网络来增强这两个小组。拟议的研究旨在实现大规模有效激活新底物所需的高催化剂活性和选择性，这将增强精细化学品应用，包括药物制造。这项建议的最大影响将是通过研究进行教育。所要求的资金用于本科生和研究生，他们将受益于获得合成有机化学，物理有机化学和过渡金属无机化学学科技能的独特机会。来自历史上在科学领域代表性不足的群体的学生也将被招募参加。Krische集团参与了一些项目，如“辉瑞少数民族研究奖学金”和NIH赞助的“通往未来的桥梁”项目，该项目促进了少数民族学生从学士/硕士到博士的过渡。学位授予机构。此外，Krische教授指导了几个学生使用NIH赞助的“研究补充，以促进健康相关研究的多样性。"

The Chemical Catalysis Program in the Chemistry Division supports Professor Michael J. Krische of the University of Texas- Austin in the US. The international collaborator, Professor Bernhard Breit of Albert-Ludwigs-Universität in Germany is supported by the German funding agency, DFG, in a collaboration that will design new routes to commodity and fine chemicals. The proposal for which this award was granted was submitted in response to Program Announcement NSF 09-608: International Collaboration in Chemistry (ICC) between US investigators and their Counterparts Abroad. The researchers propose to develop catalytic processes that enable byproduct-free manufacture of chemical products from abundant, renewable resources. The Breit Group will design and prepare a series of novel phosphine ligands that incorporate supramolecular recognition elements specifically tailored for the activation of carbonyl groups, including carbon dioxide. These "first-generation metal complexes" will be assayed in C-C bond forming hydrogenations developed by the Krische Group in order to establish key structure-reactivity and structure-selectivity trends that will allow Krische and Breit to design improved second-generation catalysts that will be prepared by the Breit Group and assayed by the Krische Group. The collaboration between the Krische and Breit groups is an ideal combination of scientific expertise that will enhance both groups through direct exposure to research techniques, approaches, philosophies, and networks across the Atlantic. The proposed research intends to achieve the high catalyst activities and selectivities necessary to activate new substrates efficiently on a large scale, which will enhance fine chemical applications, including the manufacture of pharmaceuticals. The largest impact of this proposal will be in education through research. The requested funds are for undergraduate and graduate students, who will benefit from the unique opportunity to acquire skills across the disciplines of synthetic organic chemistry, physical organic chemistry, and transition metal inorganic chemistry. Students from groups historically underrepresented in the sciences will also be recruited to participate. The Krische Group participates in programs such as the "Pfizer Research Fellowship for Under-Represented Minorities" and the NIH sponsored "Bridges to the Future" program, which facilitates the transition of minority students from BS/MS to Ph.D. degree granting institutions. Additionally, Professor Krische has mentored several students using NIH-sponsored "Research Supplements to Promote Diversity in Health-Related Research."