International Collaboration in Chemistry: Green Chemistry for Catalytic C-C Coupling of Renewable Feedstocks

国际化学合作：可再生原料催化 C-C 偶联的绿色化学

• 批准号: 1021640
• 负责人: Michael Krische
• 金额: $ 35.1万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1021640&HistoricalAwards=false
• 关键词: International; Collaboration; Chemistry; Green; Catalytic

The Chemical Catalysis Program in the Chemistry Division supports Professor Michael J. Krische of the University of Texas- Austin in the US. The international collaborator, Professor Bernhard Breit of Albert-Ludwigs-Universität in Germany is supported by the German funding agency, DFG, in a collaboration that will design new routes to commodity and fine chemicals. The proposal for which this award was granted was submitted in response to Program Announcement NSF 09-608: International Collaboration in Chemistry (ICC) between US investigators and their Counterparts Abroad. The researchers propose to develop catalytic processes that enable byproduct-free manufacture of chemical products from abundant, renewable resources. The Breit Group will design and prepare a series of novel phosphine ligands that incorporate supramolecular recognition elements specifically tailored for the activation of carbonyl groups, including carbon dioxide. These "first-generation metal complexes" will be assayed in C-C bond forming hydrogenations developed by the Krische Group in order to establish key structure-reactivity and structure-selectivity trends that will allow Krische and Breit to design improved second-generation catalysts that will be prepared by the Breit Group and assayed by the Krische Group. The collaboration between the Krische and Breit groups is an ideal combination of scientific expertise that will enhance both groups through direct exposure to research techniques, approaches, philosophies, and networks across the Atlantic. The proposed research intends to achieve the high catalyst activities and selectivities necessary to activate new substrates efficiently on a large scale, which will enhance fine chemical applications, including the manufacture of pharmaceuticals. The largest impact of this proposal will be in education through research. The requested funds are for undergraduate and graduate students, who will benefit from the unique opportunity to acquire skills across the disciplines of synthetic organic chemistry, physical organic chemistry, and transition metal inorganic chemistry. Students from groups historically underrepresented in the sciences will also be recruited to participate. The Krische Group participates in programs such as the "Pfizer Research Fellowship for Under-Represented Minorities" and the NIH sponsored "Bridges to the Future" program, which facilitates the transition of minority students from BS/MS to Ph.D. degree granting institutions. Additionally, Professor Krische has mentored several students using NIH-sponsored "Research Supplements to Promote Diversity in Health-Related Research."

化学部的化学催化计划支持美国德克萨斯大学 - 奥斯汀分校的迈克尔·克里斯切教授。国际合作者，德国Albert-Ludwigs-Universität的Bernhard Breit教授得到了德国资助机构DFG的支持，该协作将设计新的商品和精美化学品。为了应对计划公告NSF 09-608的计划公告：美国调查人员与国外同行之间的国际化学合作（ICC），提交了该奖项的提案。研究人员建议开发催化过程，以从丰富的可再生资源中实现化学产品的无副产品生产。 BREIT组将设计和准备一系列新型的磷酸配体，这些配体融合了专门针对包括羰基（包括二氧化碳）激活的超分子识别元件。这些“第一代金属络合物”将在克里斯切组开发的C-C键形成氢化中分配，以建立关键的结构反应性和结构选择趋势，这些趋势将使Krische和Breit可以设计改进的第二代催化剂，这些催化剂将由BREIT组制备，并由Krische组准备。克里斯切（Krische）和布赖特（Breit）群体之间的合作是科学专业知识的理想组合，可以通过直接接触大西洋的研究技术，方法，哲学和网络来增强这两个群体。拟议的研究旨在实现高催化剂活性和精选性，以大规模有效激活新的底物，这将增强精细的化学应用，包括制造药品。该提案的最大影响是通过研究对教育。要求的资金适用于本科生和研究生，他们将从独特的机会中受益，可以从合成有机化学，物理有机化学和过渡金属无机化学的学科中获取技能。从历史上占科学人数不足的小组的学生也将被招募参加。克里斯切集团（Krische Group）参加了诸如“代表性不足的少数群体的辉瑞研究奖学金”和NIH赞助的“未来桥梁”计划等计划，该计划设施从BS/MS到博士学位的少数学生过渡。学位授予机构。此外，Krische教授还使用了由NIH赞助的“研究补充剂来促进与健康相关的研究多样性”的研究。