Phopshine Organocatalysis

该项目代表了Krische教授对发展磷化氢催化的C-C和C-N键形成过程的努力的延续。在Krische教授小组的研究之前，Morita-Baylis-Hillman型偶联在很大程度上仅限于使用醛和醛胺作为亲电伙伴。Krische集团扩大了适用于mbh型偶联的亲电合作伙伴的范围，包括烯酮、烯丙酸酯和芳烃。在拟议的资助期内，将设计这些转化的对映选择性变体，并将开发其他磷化氢催化过程。通过这个奖项，有机和大分子化学项目支持德克萨斯大学奥斯汀分校化学和生物化学系的Michael J. Krische教授的研究。Krische教授的研究项目主要集中在催化反应的发展，特别是C-C和C-N键形成的无副产物过程。所提议的方法的成功发展将对制药和农用化学工业中的合成有机化学产生巨大的积极影响。

This project represents a continuation of Professor Krische's efforts toward the development of phosphine catalyzed C-C and C-N bond forming processes. Prior to studies from Professor Krische's group, Morita-Baylis-Hillman type couplings were largely restricted to the use of aldehydes and aldimines as electrophilic partners. The Krische group has expanded the range of electrophilic partners applicable to MBH-type coupling to encompass enones, allylic acetates and arenes. In the proposed funding period, enantioselective variants of these transformations will be devised and other phosphine catalyzed processes will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Michael J. Krische at the Department of Chemistry and Biochemistry at the University of Texas at Austin. Professor Krische's research program focuses on catalytic reaction development, in particular on byproduct-free processes for C-C and C-N bond formation. The successful development of the proposed methodologies will have a large positive impact on synthetic organic chemistry in the pharmaceutical and agrochemical industries.