Phopshine Organocatalysis

该项目代表了Krische教授对膦催化的C-C和C-N键形成过程的发展所做努力的延续。在Krische教授小组的研究之前，Morita-Baylis-Hillman型偶联主要限于使用醛和醛亚胺作为亲电伙伴。Krische小组已经扩大了适用于MBH型偶联的亲电伙伴的范围，包括烯酮、乙酸烯丙酯和芳烃。在拟议的资助期内，将设计这些转化的对映选择性变体，并开发其他膦催化工艺。有了这个奖项，有机和大分子化学计划正在支持德克萨斯大学奥斯汀分校化学和生物化学系的Michael J. Krische教授的研究。 Krische教授的研究项目侧重于催化反应的开发，特别是C-C和C-N键形成的无副产物过程。 所提出的方法的成功开发将对制药和农业化学工业中的合成有机化学产生巨大的积极影响。

This project represents a continuation of Professor Krische's efforts toward the development of phosphine catalyzed C-C and C-N bond forming processes. Prior to studies from Professor Krische's group, Morita-Baylis-Hillman type couplings were largely restricted to the use of aldehydes and aldimines as electrophilic partners. The Krische group has expanded the range of electrophilic partners applicable to MBH-type coupling to encompass enones, allylic acetates and arenes. In the proposed funding period, enantioselective variants of these transformations will be devised and other phosphine catalyzed processes will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Michael J. Krische at the Department of Chemistry and Biochemistry at the University of Texas at Austin. Professor Krische's research program focuses on catalytic reaction development, in particular on byproduct-free processes for C-C and C-N bond formation. The successful development of the proposed methodologies will have a large positive impact on synthetic organic chemistry in the pharmaceutical and agrochemical industries.