Phopshine Organocatalysis

这个项目代表了Krische教授在磷化氢催化的C-C和C-N键形成过程开发方面的继续努力。在Krische教授的研究小组进行研究之前，Morita-Baylis-Hillman类型的联轴器在很大程度上仅限于使用醛和乙二胺作为亲电伙伴。Krische小组将适用于MBH型偶联的亲电伙伴范围扩大到包括烯酮、烯丙基乙酸酯和芳烃。在拟议的资助期内，将设计这些转化的对映选择性变体，并开发其他磷化氢催化的过程。有了这个奖项，有机和高分子化学计划将支持德克萨斯大学奥斯汀分校化学和生物化学系的迈克尔·J·克里什教授的研究。Krische教授的研究计划侧重于催化反应的发展，特别是无副产物的C-C和C-N键形成过程。所提出的方法的成功开发将对制药和农化工业中的合成有机化学产生巨大的积极影响。

This project represents a continuation of Professor Krische's efforts toward the development of phosphine catalyzed C-C and C-N bond forming processes. Prior to studies from Professor Krische's group, Morita-Baylis-Hillman type couplings were largely restricted to the use of aldehydes and aldimines as electrophilic partners. The Krische group has expanded the range of electrophilic partners applicable to MBH-type coupling to encompass enones, allylic acetates and arenes. In the proposed funding period, enantioselective variants of these transformations will be devised and other phosphine catalyzed processes will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Michael J. Krische at the Department of Chemistry and Biochemistry at the University of Texas at Austin. Professor Krische's research program focuses on catalytic reaction development, in particular on byproduct-free processes for C-C and C-N bond formation. The successful development of the proposed methodologies will have a large positive impact on synthetic organic chemistry in the pharmaceutical and agrochemical industries.