U.S.-Turkey Planning Visit: Collaborative Research on the Development of Biosensors for DNA Mutations Assay, July 2010

Li Oise-1036579本项目“美土规划访问：DNA突变分析生物传感器开发中的合作研究”，2010年7月，资助佛罗里达国际大学的陈忠博士和三名研究生前往土耳其，会见伊兹密尔Ege大学的Arzum E.Gursan博士和伊斯坦布尔技术大学的Nilgan Batdogan博士，以获取纳米材料制备和阻抗建模方面的知识，并为即将提交给NSF和TUBITAK(土耳其的NSF对应机构)的美土合作项目制定可行的计划。他们还计划参观伊斯坦布尔的科克大学，参观其微纳米技术研究中心。智力优势：计划的研究的优点包括提高对使用新型磁性纳米颗粒为基础的电化学阻抗DNA生物传感器检测DNA突变的理解。这些理解包括传感芯片的设计细节、磁性纳米颗粒的合成和功能化、电化学阻抗技术培训和数据建模。最终，这一认识将被用于测试开发基于芯片的DNA生物传感器的可行性。这一合作将通过在两个小组之间共享互补的专业知识和研究资源来实现研究，并创建一个将应对纳米技术领域的关键挑战的项目。广泛影响：访问团队由PI和三名研究生组成，他们在MEMS/NEMS制造和生物医学设备测试方面拥有广泛的专业知识和不同水平的经验。该项目有可能为社会创造更广泛的利益，因为DNA生物传感器技术可能会商业化，从而将这些努力的范围扩大到基础研究之外。一名研究生将主要接受磁性纳米颗粒的合成和功能化方面的培训。另一名研究生将专注于电化学阻抗技术和数据建模的培训，第三名研究生将通过专门针对设备设计的程序(如AUTOCAD)将经验带给古尔桑？S博士实验室的学生。获得的初步结果将用于NSF-TUBITAK提案。这些年轻的研究人员将接触到国际上最先进的设施。此外，在国际经验之后，将继续进行基于网络的交流，以培养S学生这两个群体之间的持续关系。这些项目活动将推动新技术的开发，同时促进教学、培训和学习，并在美国和土耳其之间建立生物传感器研究方面的牢固联系。该项目由化学、生物工程、环境和运输系统司(CBET)和国际科学与工程办公室(OISE)共同资助。

Li OISE-1036579This project "US-Turkey Planning Visit: Collaborative Research in the Development of Biosensors for DNA Mutations Assay, July 2010" supports the travel of Dr. Chenzhong, Florida International University and three graduate students to Turkey to meet with Dr. Arzum E. Gursan at Ege University in Izmir and with Dr. Nilgun Batdogan at Istanbul Technical University to gain knowledge of nanomaterial preparation and impedance modeling and to develop a viable plan for a US-Turkey collaborative project to be submitted to NSF and to TUBITAK (NSF counterpart in Turkey). They also plan to visit Koc University in Istanbul to visit its micro-nanotechnologies research center.Intellectual Merits: The merits of the planned research include an improved understanding of DNA mutant detection using a novel magnetic nanoparticle based electrochemical impedance DNA biosensor. This understanding includes detail of the design of the sensing chip, synthesis and functionalization of magnetic nanoparticles, training of electrochemical impedance technique and data modeling. Eventually this understanding will be applied to test the feasibility of developing chip based DNA biosensors. This collaboration will enable the research by sharing complementary expertise and research resources between the two groups and create a project that will address a critical challenge in the field of nanotechnology.Broader Impacts: The visiting team consists of the PI and three graduate students with a spread of expertise and varying levels of experience working on the MEMS/NEMS fabrication and biomedical device testing. The project has the potential to create broader benefits to society with the possible commercialization of the DNA biosensor technology to expand the scope of these efforts beyond fundamental research. One graduate student will be primarily trained on the synthesis and functionalization of magnetic nanoparticles. The other graduate student will focus on the training of electrochemical impedance technique and the data modeling and the third will bring the experiences to the students in Dr. Gursan?s lab in a program specific for device design such as AUTOCAD. The preliminary results obtained will be used for the NSF- TUBITAK proposal. The young researchers will be exposed to state-of the-art facilities in an international setting. Additionally, web-based communication will be on-going after the international experience to foster a continuing relationship between the two group?s students. The project activities will advance new technology development while promoting teaching, training and learning and establishing strong ties between the U.S. and Turkey in biosensor research. This project is co-funded by the Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) and the Office of International Science and Engineering (OISE).