U.S.-Turkey Planning Visit: Collaborative Research on the Development of Biosensors for DNA Mutations Assay, July 2010

Li OISE-1036579本项目“美国-土耳其计划访问：DNA突变检测生物传感器开发的合作研究，2010年7月”支持佛罗里达国际大学陈忠博士和三名研究生前往土耳其与Arzum E. Gursan在伊兹密尔的Ege大学和伊斯坦布尔技术大学的Nilgun Batdogan博士，以获得纳米材料制备和阻抗建模的知识，并为提交给NSF和TUBITAK（NSF在土耳其的对应机构）的美国-土耳其合作项目制定可行的计划。 他们还计划访问位于伊斯坦布尔的Koc大学，参观其微纳米技术研究中心。智力优势：计划研究的优点包括使用基于新型磁性纳米颗粒的电化学阻抗DNA生物传感器来提高对DNA突变检测的理解。这种理解包括传感芯片的设计细节，磁性纳米颗粒的合成和功能化，电化学阻抗技术的培训和数据建模。 最终，这种理解将被应用于测试开发基于芯片的DNA生物传感器的可行性。此次合作将使研究通过共享互补的专业知识和研究资源之间的两个小组，并创建一个项目，将解决在纳米技术领域的一个关键挑战。更广泛的影响：访问团队由PI和三个研究生组成的专业知识和不同层次的经验，在MEMS/NEMS制造和生物医学设备测试工作的传播。该项目有可能为社会创造更广泛的利益，因为DNA生物传感器技术有可能商业化，从而将这些努力的范围扩大到基础研究之外。 一名研究生将主要接受磁性纳米颗粒的合成和功能化的培训。另一名研究生将专注于电化学阻抗技术和数据建模的培训，第三名研究生将把经验带给Gursan博士的学生。在实验室的一个专用于器件设计的程序中，如AUTOCAD。获得的初步结果将用于国家科学基金会-土耳其科学技术研究理事会的提案。年轻的研究人员将在国际环境中接触最先进的设施。此外，基于网络的通信将在国际经验后继续进行，以促进两个集团之间的持续关系？的学生。该项目活动将推动新技术的发展，同时促进教学，培训和学习，并在美国和土耳其之间建立牢固的生物传感器研究联系。该项目由化学、生物工程、环境和运输系统司（CBET）和国际科学与工程办公室（OISE）共同资助。

Li OISE-1036579This project "US-Turkey Planning Visit: Collaborative Research in the Development of Biosensors for DNA Mutations Assay, July 2010" supports the travel of Dr. Chenzhong, Florida International University and three graduate students to Turkey to meet with Dr. Arzum E. Gursan at Ege University in Izmir and with Dr. Nilgun Batdogan at Istanbul Technical University to gain knowledge of nanomaterial preparation and impedance modeling and to develop a viable plan for a US-Turkey collaborative project to be submitted to NSF and to TUBITAK (NSF counterpart in Turkey). They also plan to visit Koc University in Istanbul to visit its micro-nanotechnologies research center.Intellectual Merits: The merits of the planned research include an improved understanding of DNA mutant detection using a novel magnetic nanoparticle based electrochemical impedance DNA biosensor. This understanding includes detail of the design of the sensing chip, synthesis and functionalization of magnetic nanoparticles, training of electrochemical impedance technique and data modeling. Eventually this understanding will be applied to test the feasibility of developing chip based DNA biosensors. This collaboration will enable the research by sharing complementary expertise and research resources between the two groups and create a project that will address a critical challenge in the field of nanotechnology.Broader Impacts: The visiting team consists of the PI and three graduate students with a spread of expertise and varying levels of experience working on the MEMS/NEMS fabrication and biomedical device testing. The project has the potential to create broader benefits to society with the possible commercialization of the DNA biosensor technology to expand the scope of these efforts beyond fundamental research. One graduate student will be primarily trained on the synthesis and functionalization of magnetic nanoparticles. The other graduate student will focus on the training of electrochemical impedance technique and the data modeling and the third will bring the experiences to the students in Dr. Gursan?s lab in a program specific for device design such as AUTOCAD. The preliminary results obtained will be used for the NSF- TUBITAK proposal. The young researchers will be exposed to state-of the-art facilities in an international setting. Additionally, web-based communication will be on-going after the international experience to foster a continuing relationship between the two group?s students. The project activities will advance new technology development while promoting teaching, training and learning and establishing strong ties between the U.S. and Turkey in biosensor research. This project is co-funded by the Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) and the Office of International Science and Engineering (OISE).