MRI: Aquisition of an EPR Spectrometer

MRI：购买 EPR 波谱仪

• 批准号: 1039845
• 负责人: Richard Holz
• 金额: $ 22.21万
• 依托单位: Loyola University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1039845&HistoricalAwards=false
• 关键词: MRI; Aquisition; EPR; Spectrometer

With this award, co-funded by the Division of Chemistry and the Major Research Instrumentation (MRI) program, Professor Richard Holz from Loyola University of Chicago will acquire an electron paramagnetic resonance spectrometer equipped with low temperature liquid helium capabilities and an X band cavity operational in both perpendicular and parallel modes. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as investigations of metallohydrolases and metallohydratases, biologically relevant metal centers, catalytic role of the dinuclear metal binding site in ADP glucose pyrophosphorylase, electronic and catalytic properties of the dinuclear active site of Aminopeptidase P, Mn(II) and divalent VO metal substituted derivatives of alpha subunits of guanine nucleotide binding proteins and copper, zinc superoxide dismutase and applications of X band EPR at low temperatures.An EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels.

芝加哥洛约拉大学的 Richard Holz 教授将获得由化学部和主要研究仪器 (MRI) 项目共同资助的这一奖项，获得一台配备低温液氦功能和可在垂直和平行模式下运行的 X 带腔的电子顺磁共振波谱仪。该提案旨在加强各级研究培训和教育，特别是在金属水解酶和金属水合酶、生物学相关金属中心、ADP葡萄糖焦磷酸化酶中双核金属结合位点的催化作用、氨基肽酶P、Mn(II)和二价VO金属取代的双核活性位点的电子和催化特性等研究领域。 鸟嘌呤核苷酸结合蛋白的α亚基衍生物和铜、锌超氧化物歧化酶以及X带EPR在低温下的应用。EPR光谱仪可提供分子和固态材料的几何和电子结构的详细信息。它还可用于获取有关自由​​基、短命、高活性物质的寿命的信息，这些物质参与有价值的化学转化以及病理性肿瘤生长的启动。这些研究将影响许多领域，从无机和有机分子的合成到新型固态材料的开发，再到具有生物意义的化合物。该工具采用受正在进行的研究启发的示例，将成为本科生和研究生水平研究和教学的一个组成部分。