MRI: Aquisition of an EPR Spectrometer

在化学系和主要研究仪器(MRI)计划的共同资助下，芝加哥洛约拉大学的理查德·霍尔茨教授将获得一台配备低温液氦能力的电子顺磁共振光谱仪和一个可在垂直和平行模式下运行的X波段空腔。该建议旨在加强各级的研究培训和教育，特别是在研究领域，如金属水解酶和金属水解酶，生物相关的金属中心，双核金属结合位点在ADP葡萄糖焦磷酸化酶中的催化作用，氨基肽酶P，Mn(II)和鸟嘌呤核苷酸结合蛋白的α亚基和铜，锌超氧化物歧化酶的二价VO金属取代的双核活性中心的电子和催化性质，以及X带EPR在低温下的应用。EPR光谱仪提供了分子和固体材料的几何和电子结构的详细信息。它还可以用来获得有关自由基寿命的信息，自由基是参与有价值的化学转化的短暂、高活性物种，以及启动病理性肿瘤生长的信息。这些研究将影响许多领域，从无机和有机分子的合成到新的固态材料的开发，再到具有生物意义的化合物。利用从正在进行的研究启发的例子，该仪器将成为本科生和研究生水平研究和教学的组成部分。

With this award, co-funded by the Division of Chemistry and the Major Research Instrumentation (MRI) program, Professor Richard Holz from Loyola University of Chicago will acquire an electron paramagnetic resonance spectrometer equipped with low temperature liquid helium capabilities and an X band cavity operational in both perpendicular and parallel modes. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as investigations of metallohydrolases and metallohydratases, biologically relevant metal centers, catalytic role of the dinuclear metal binding site in ADP glucose pyrophosphorylase, electronic and catalytic properties of the dinuclear active site of Aminopeptidase P, Mn(II) and divalent VO metal substituted derivatives of alpha subunits of guanine nucleotide binding proteins and copper, zinc superoxide dismutase and applications of X band EPR at low temperatures.An EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels.