EAGER: Nonlinear spectroscopic method to measure biomolecule affinity constants

EAGER：测量生物分子亲和常数的非线性光谱方法

• 批准号: 1041980
• 负责人: Kenneth Eisenthal
• 金额: $ 30万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1041980&HistoricalAwards=false
• 关键词: EAGER; Nonlinear; spectroscopic; method; measure

In this Early Concept Grant for Exploratory Research, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Eisenthal from Columbia University will measure affinity constants between biomolecules by the application of nonlinear spectroscopic techniques. Affinity constants are used to characterize the strength of interactions from biomolecule to biomolecule. The new non-linear optical method responds to changes in electric charge in the solid/water interface when free biomolecules from the solution complex with biomolecules that are bound to the solid side of the interface. The proposed technique may provide a new path in the search for novel drug therapies.

在这项由化学系化学测量和成像计划资助的探索性研究早期概念基金中，哥伦比亚大学的艾森塔尔教授将通过应用非线性光谱技术来测量生物分子之间的亲和力常数。亲和力常数用来表征生物分子与生物分子之间相互作用的强度。当溶液中的游离生物分子与结合在固/水界面上的生物分子络合时，新的非线性光学方法响应固体/水界面上电荷的变化。这项技术可能为寻找新的药物疗法提供一条新的途径。