Sum frequency studies of liquid interfaces

在这个由化学系化学结构，动力学和机制A（CSDM-A）计划资助的奖项中，哥伦比亚大学的Kenneth Eisenthal教授和他的博士后和研究生同事正在研究生物分子在界面上的相互作用。Eisenthal教授和他的团队工作的最终目标是更好地理解生物分子与其他分子相互作用的物理和化学。 像这样的研究可能会导致更好的方法来测量生物分子与药物和其他生物分子之间的相互作用强度。 在艾森塔尔教授的实验室工作的年轻研究人员将接受培训，以从事技术工作。艾森塔尔教授和他的小组正在进行实验，利用非线性光谱方法研究生物分子在微粒界面上的行为，包括：（1）测量小分子与DNA的结合常数;（2）测量小分子与同一DNA结合的相对取向;（3）测量小分子与DNA结合的相对取向。（3）研究netropsin与DNA结合引起的DNA形变;（4）研究等离子体增强的二次谐波产生，用于生物分子研究。 Eisenthal教授在他的实验室教育和指导年轻科学家，他们继续在学术界，工业界和该国的国家实验室任职。

In this award, funded by the Chemical Structure, Dynamics and Mechanisms A (CSDM-A) Program of the Division of Chemistry, Professor Kenneth Eisenthal of Columbia University and his post-doctoral and graduate student colleagues are investigating the interactions of biomolecules at interfaces. The ultimate goal of the work by Professor Eisenthal and his group is to develop a better understanding of the physics and chemistry of biomolecules interacting with other molecules. Research like this could lead to better way of measuring the strength of interactions between biomolecules and drugs and other biomolecules. Young researchers working in Prof. Eisenthal's laboratory will be trained for jobs in the technical workforce.Prof. Eisenthal and his group are carrying out experiments using non-linear spectroscopic methods to investigate the behavior of biomolecules at microparticle interfaces including: (1) measurement of binding constants for small molecules with DNA; (2) measuring the relative orientation of small molecules bound to the same DNA; (3) studying the deformation of DNA induced by netropsin binding; (4) studying the plasmonic enhancement of secondharmonic generation for biomolecular studies. Prof. Eisenthal educates and mentors the young scientists in his laboratory, who go on to positions in academia, industry and the country's National Laboratories.