Sum frequency studies of liquid interfaces

液体界面的和频研究

• 批准号: 1360969
• 负责人: Kenneth Eisenthal
• 金额: $ 66万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1360969&HistoricalAwards=false
• 关键词: Sum; frequency; studies; liquid; interfaces

In this award, funded by the Chemical Structure, Dynamics and Mechanisms A (CSDM-A) Program of the Division of Chemistry, Professor Kenneth Eisenthal of Columbia University and his post-doctoral and graduate student colleagues are investigating the interactions of biomolecules at interfaces. The ultimate goal of the work by Professor Eisenthal and his group is to develop a better understanding of the physics and chemistry of biomolecules interacting with other molecules. Research like this could lead to better way of measuring the strength of interactions between biomolecules and drugs and other biomolecules. Young researchers working in Prof. Eisenthal's laboratory will be trained for jobs in the technical workforce.Prof. Eisenthal and his group are carrying out experiments using non-linear spectroscopic methods to investigate the behavior of biomolecules at microparticle interfaces including: (1) measurement of binding constants for small molecules with DNA; (2) measuring the relative orientation of small molecules bound to the same DNA; (3) studying the deformation of DNA induced by netropsin binding; (4) studying the plasmonic enhancement of secondharmonic generation for biomolecular studies. Prof. Eisenthal educates and mentors the young scientists in his laboratory, who go on to positions in academia, industry and the country's National Laboratories.

该奖项由化学系化学结构、动力学和机制A （CSDM-A）项目资助，哥伦比亚大学的Kenneth Eisenthal教授和他的博士后和研究生同事正在研究生物分子在界面上的相互作用。Eisenthal教授和他的团队的最终目标是更好地理解生物分子与其他分子相互作用的物理和化学。这样的研究可能会带来更好的方法来测量生物分子与药物和其他生物分子之间相互作用的强度。在艾森塔尔教授实验室工作的年轻研究人员将接受技术工作人员的培训。Eisenthal和他的团队正在进行实验，使用非线性光谱方法来研究生物分子在微粒界面上的行为，包括：(1)测量小分子与DNA的结合常数；(2)测量与同一DNA结合的小分子的相对取向；(3)研究netropsin结合诱导的DNA变形；(4)生物分子研究中二次谐波产生的等离子体增强。Eisenthal教授在他的实验室里教育和指导年轻的科学家，他们后来在学术界、工业界和国家实验室担任职务。