Dimensions: Genomics, functional roles, and diversity of the symbiotic gut microbiotae of honey bees and bumble bees
维度:蜜蜂和熊蜂共生肠道微生物群的基因组学、功能作用和多样性
基本信息
- 批准号:1046153
- 负责人:
- 金额:$ 200.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-01-01 至 2014-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Microbial gut symbionts are essential for the life of most animal species, but their diversity and functions in hosts and their responses to ecological disturbance are poorly understood. Apis mellifera, the honeybee, possesses a distinctive set of about eight symbiotic bacterial species; some of these also occur in other Apis species and in the related genus Bombus (bumblebees). This study integrates the genomic, taxonomic and functional dimensions of the biodiversity of gut symbionts in these bees. The research will determine genome sequences and metabolic capabilities for these bacterial species and probe how their abundances and gene expression respond when hosts are subjected to different environments. The consequences of altered microbiota for host fitness will be experimentally assessed under nutrient stress and pathogen challenge. The study will also characterize the taxonomic composition of the microbiota of Bombus and Apis species collected globally, with emphasis on North America and China.These pollinator species have immense economic, ecological, and agricultural importance; this project will provide new insights into their ecological resilience as mediated by their gut microbes. The data will inform bee conservation and land management policies. This effort will also establish a collaborative exchange with Chinese scientists. Several US students, at different levels, will be trained. High school student researchers and educational activities will be sponsored through the Peabody Museum in New Haven, CT. A large global collection of cryopreserved bees will be established to serve as a reference resource for future changes in bee populations. Overall, this research will provide novel insights into the biology of these important pollinators and their symbiotic microbial biodiversity.
微生物肠道共生菌是大多数动物生命所必需的,但它们在宿主中的多样性和功能以及它们对生态干扰的反应却知之甚少。意大利蜜蜂是蜜蜂,拥有一套独特的约8种共生细菌;其中一些也存在于其他蜜蜂物种和相关的熊蜂属(熊蜂)中。这项研究整合了这些蜜蜂肠道共生体生物多样性的基因组、分类学和功能维度。这项研究将确定这些细菌物种的基因组序列和代谢能力,并探索它们的丰度和基因表达在宿主受到不同环境影响时的反应。在营养胁迫和病原体挑战下,将通过实验评估微生物区系改变对宿主适应性的影响。这项研究还将描述全球收集的Bombus和Apis物种微生物区系的分类组成,重点是北美和中国。这些传粉物种具有巨大的经济、生态和农业重要性;该项目将为了解它们由肠道微生物介导的生态弹性提供新的见解。这些数据将为蜜蜂保护和土地管理政策提供信息。这一努力还将建立与中国科学家的合作交流。几名不同级别的美国学生将接受培训。高中生研究人员和教育活动将通过位于康涅狄格州纽黑文的皮博迪博物馆赞助。将建立一个大规模的全球冷冻蜜蜂集合,作为未来蜜蜂种群变化的参考资源。总体而言,这项研究将为这些重要传粉者的生物学及其共生微生物生物多样性提供新的见解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nancy Moran其他文献
P01-008-23 Relative Validity of Nutrition Assessment Tools for Estimating Infant Carotenoid Intake
- DOI:
10.1016/j.cdnut.2023.100215 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:
- 作者:
Shivanki Juneja;Jocelyn Chang;Robert Castaneda;Salma Musaad;Teresia O'Connor;Nancy Moran - 通讯作者:
Nancy Moran
アブラムシはボルバキアから得た遺伝子を利用してブフネラを制御する?
蚜虫是否利用沃尔巴克氏体的基因来控制 Buchnera?
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
中鉢淳;John McCutcheon;工藤俊章;宮城島進也;Nancy Moran;二河成男 - 通讯作者:
二河成男
アブラムシゲノムにコードされ、共生器官で高発現する細菌由来水平転移遺伝子群
蚜虫基因组中编码的细菌水平转移基因在共生器官中高表达
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
中鉢淳;John McCutcheon;工藤俊章;宮城島進也;Nancy Moran;二河成男 - 通讯作者:
二河成男
Infant Heel Dermal Carotenoids Are Measured Rapidly and Reliably by Portable Reflection Spectroscopy
- DOI:
10.1093/cdn/nzaa041_026 - 发表时间:
2020-06-01 - 期刊:
- 影响因子:
- 作者:
Nancy Moran;Noor Hason;Jocelyn Chang;Teresia O’Connor - 通讯作者:
Teresia O’Connor
B-33 Relationship between lifestyle factors and oxygen saturation in air medical crew members: A pilot study
- DOI:
10.1016/s0894-8321(88)80154-2 - 发表时间:
1988-09-01 - 期刊:
- 影响因子:
- 作者:
Cathy Peterson;Karen Augeneder;Lynn Eastes;Marsha Somers;Nancy Moran - 通讯作者:
Nancy Moran
Nancy Moran的其他文献
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{{ truncateString('Nancy Moran', 18)}}的其他基金
DISSERTATION RESEARCH: Competition and cooperation in the honey bee gut microbiota
论文研究:蜜蜂肠道微生物群的竞争与合作
- 批准号:
1701430 - 财政年份:2017
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
Elucidating the coevolutionary dynamics in an obligate insect symbiosis
阐明专性昆虫共生中的共同进化动力学
- 批准号:
1551092 - 财政年份:2016
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
Host-mediated regulation of dual obligate intracellular symbionts
宿主介导的双专性细胞内共生体的调节
- 批准号:
1347116 - 财政年份:2014
- 资助金额:
$ 200.64万 - 项目类别:
Continuing Grant
Dimensions: Genomics, functional roles, and diversity of the symbiotic gut microbiotae of honey bees and bumble bees
维度:蜜蜂和熊蜂共生肠道微生物群的基因组学、功能作用和多样性
- 批准号:
1415604 - 财政年份:2013
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
En-Gen: Mutation in Genomes of Obligate Symbionts and Impacts on the Ecological Tolerances and Distributions of Hosts: Buchnera and Pea Aphids
En-Gen:专性共生体基因组突变及其对生态耐受性和宿主分布的影响:Buchnera 和豌豆蚜
- 批准号:
1106195 - 财政年份:2010
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
Highly Reduced Genomes of Coresident Bacterial Symbionts of Xylem-Feeding Insects: Ecological and Evolutionary Implications
木质部喂养昆虫的共存细菌共生体的高度减少的基因组:生态和进化意义
- 批准号:
1062363 - 财政年份:2010
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
En-Gen: Mutation in Genomes of Obligate Symbionts and Impacts on the Ecological Tolerances and Distributions of Hosts: Buchnera and Pea Aphids
En-Gen:专性共生体基因组突变及其对生态耐受性和宿主分布的影响:Buchnera 和豌豆蚜
- 批准号:
0723472 - 财政年份:2008
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
Genome dynamics of protective bacterial symbionts in insects
昆虫保护性细菌共生体的基因组动力学
- 批准号:
0709992 - 财政年份:2007
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
Highly Reduced Genomes of Coresident Bacterial Symbionts of Xylem-Feeding Insects: Ecological and Evolutionary Implications
木质部喂养昆虫的共存细菌共生体的高度减少的基因组:生态和进化意义
- 批准号:
0626716 - 财政年份:2006
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
Discovery and Characterization of Bacterial Endosymbiont Diversity in Drosophila
果蝇细菌内共生多样性的发现和表征
- 批准号:
0315815 - 财政年份:2003
- 资助金额:
$ 200.64万 - 项目类别:
Standard Grant
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