SBIR Phase I: A Batteryless Wireless Impedance Sensor System For Gastroesophageal Reflux Diagnosis

SBIR 第一阶段：用于胃食管反流诊断的无电池无线阻抗传感器系统

• 批准号: 1046488
• 负责人: Smitha Hatti
• 金额: $ 15万
• 依托单位: Talus Atomics Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1046488&HistoricalAwards=false
• 关键词: SBIR; Phase; Batteryless; Wireless; Impedance

This Small Business Innovation Research (SBIR) Phase I project explores advanced technologies to develop a transformative miniature batteryless wireless impedance sensor that is suitable for endoscopic implantation through the mouth and esophagus for the comfort and convenience of patients in the diagnosis and prognosis of gastroesophageal reflux disease (GERD). An implantable miniature batteryless wireless device that does not require externally tethered connections and has the ability to detect acid and nonacid episodes is preferred for esophageal reflux monitoring by both patients and doctors. The proposed system consists of a miniature nanowire-based sensor which can be attached on esophagus wall for a long period of time and an external wearable reader. The impedance variations from the sensor can indicate episodes of reflux that are both acidic and non-acidic in nature. The intellectual merits in this project include the optimization of wireless power transfer efficiency for human implant applications, low-power circuitry design and miniature device fabrication/packaging, sensor surface modification with silicon nanowires, and characterization of the entire wireless sensor system.The broader impact/commercial potential of this project will enhance greatly the scientific and technological understanding of passive wireless communication for miniature medical implants, improve healthcare procedures, reduce healthcare costs, and enable accurate measurements for regular screening methods to prevent the occurrence of incurable esophageal cancers. The proposed system provides an innovative and practical solution for gastroesophageal reflux monitoring with advantages of batteryless operation, portable wireless communication, impedance sensing method, and miniature size enabling comfortable endoscopic implantation. With these advantages, clinicians can precisely diagnose reflux with electronic records showing quantitative data with cost-effective and out-patient procedures that can be used for large population and potentially periodic screening. With 19 million adults who have consistent reflux symptoms in US and the global aging population, the proposed system for diagnosis and prognosis will have a significant impact on healthcare procedures and costs. With improved comfort level and accuracy, the system will enable regular screening procedures in clinics which in return offer a great commercial potential with a sustainable market size. The technology development also addresses commercial potentials for applications and manufacturing of semiconductor chips in miniature medical implants and portable wireless electronics in body sensor networking

这项小型企业创新研究（SBIR）一期项目探索先进技术，开发一种变革性的微型无电池无线阻抗传感器，适用于通过口腔和食道的内镜植入，为胃食管反流病（GERD）患者的诊断和预后提供舒适和方便。一种可植入的微型无电池无线设备，不需要外部连接，具有检测酸和非酸发作的能力，是患者和医生监测食管反流的首选。该系统由一个可以长时间附着在食管壁上的微型纳米线传感器和一个外部可穿戴读取器组成。来自传感器的阻抗变化可以指示酸性和非酸性回流的发作。本计画的智慧优势包括：优化人体植入应用的无线电力传输效率、低功耗电路设计和微型装置制造/封装、用矽奈米线修饰感测器表面，以及整个无线感测器系统的特性。该项目的广泛影响/商业潜力将大大提高对微型医疗植入物无源无线通信的科学和技术理解，改善医疗保健程序，降低医疗保健成本，并使常规筛查方法能够精确测量，以防止无法治愈的食管癌的发生。该系统为胃食管反流监测提供了一种创新实用的解决方案，该系统具有无电池操作、便携式无线通信、阻抗传感方法、微型尺寸、舒适的内镜植入等优点。有了这些优势，临床医生可以精确地诊断反流的电子记录显示定量数据与成本效益和门诊程序，可用于大人群和潜在的定期筛查。在美国和全球老龄化人口中，有1900万成年人有持续的反流症状，因此拟议的诊断和预后系统将对医疗程序和成本产生重大影响。随着舒适度和准确性的提高，该系统将使诊所能够定期进行筛查，从而提供巨大的商业潜力和可持续的市场规模。该技术开发还解决了微型医疗植入物中半导体芯片的应用和制造以及身体传感器网络中的便携式无线电子设备的商业潜力