RAPID: Collaborative Research: Genetic Impact of the Deepwater Horizon Oil Release

这项RAPID提案汇集了受深水地平线（DH）石油泄漏影响的州的大学之间的合作。随着数百万加仑的石油泄漏，分散剂的使用以及地下石油“爆发”进入海湾和河口的可能性，可能会对人类和自然种群造成前所未有的人为影响。本研究将利用大底藻鱼（Fundulus grandis）来确定DH油释放的生理和进化影响，大底藻是墨西哥湾沿岸河口的一种天然生物。通过应用尖端技术，将描述人类对这种环境的影响的遗传影响，从而提供基线数据，以记录石油污染对遗传多样性的影响，以及在限制漏油对生物多样性的负面影响方面补救措施的有效性。这些数据将告知社会关于DH石油泄漏的短期和长期影响，这在最近的基因组技术创新之前是不可能的。基因组技术的应用可以深入了解受DH油影响的基因，以及清理工作是否有效地减少了遗传多样性的损失。因此，这项研究应该为BP清理工作的有效性提供证据。此外，通过测量DH油对鱼类基因组学的影响，将收集到与人类健康有关的基因的额外信息。简单地说，通过测量暴露于DH油中的鱼的基因，可能对人类健康也很重要的基因将被识别出来。

This RAPID proposal brings together a collaboration among Universities in states affected by the Deepwater Horizon (DH) oil release. With the millions of gallons of oil released, the use of dispersants and the likelihood of movement of the subsurface oil "bloom" into bays and estuaries, an unprecedented anthropogenic impact on human and natural populations may result. This study will define the physiological and evolutionary impact of the DH oil release using the fish Fundulus grandis, a natural inhabitant of estuaries along the Gulf of Mexico. By applying cutting edge technologies, the genetic effects of man's impact on this environment will be described and, thus, provide the baseline data to document the effect of oil pollution on genetic diversity and effectiveness of remediation in limiting negative biodiversity consequences of the spill. These data will inform society about the short and long-term impacts of the DH oil spill, which has not been possible prior to the recent innovation in genomic techniques. The application of genomic technology provides insights into the genes affected by DH oil and whether cleanup efforts effectively minimize loss of genetic diversity. Thus, this research should provide the evidence of the effectiveness of BP cleanup efforts. Additionally, by measuring the impact of DH oil on fish genomics, additional information will be gathered regarding the genes that matter for human health. Simply put, by measuring the genes in fish that survive exposure to DH oil, genes that may also be important for human health will be identified.