权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Räumlich-zeitliche Dynamik verteilter Netzwerk-Aktivität als Determinate zielgerichteter Verhaltensabfolgen im Nervensystem des Wirbeltiers

分布式网络活动的时空动力学作为脊椎动物神经系统目标导向行为序列的决定因素

基本信息

批准号：
200282842
负责人：
Professor Dr. Johann Heinrich Bollmann
金额：
--
依托单位：
Abteilung Entwicklungsbiologie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/200282842?language=en
关键词：
umlich zeitliche Dynamik verteilter Netzwerk

项目摘要

Goal-directed behaviors are composed of several sequentially executed motor steps, which may involve eye, head and reaching movements. A goal-directed behavioral sequence is triggered by external sensory stimuli. Subsequent elements of the sequence, and its successful completion, depend on sensory feedback between steps, on the internal monitoring of motor commands, and on internal state variables such as attention, expectation and motivation. During multi-step sequences, different types of neurons in the midbrain tectum and in brain stem nuclei exhibit firing patterns that correlate with features of the sensory stimulus, or with aspects involved in planning, selection and execution of the motor pattern. We plan to investigate the unsolved question of how these different neuronal ensembles control multi-step sequences in the visuo-motor system of the larval zebrafish (Danio rerio). Owing to its small size, transparent skin and genetic malleability, this vertebrate model offers unique opportunities to image the neural dynamics of distributed networks in relation to goal-directed visually guided behaviors in the intact animal. Specifically, we plan to test whether multi-step behavioral sequences are composed of a discrete set of motor patterns. We will also test whether specific spatio-temporal distributions of activity exist in the optic tectum and reticulo-spinal system that encode individual steps of a multi-step sequence. Finally, we will address the question how the dynamics of neural activity and short-term plasticity affect the coupling between individual motor steps as a determinant of the efficiency of a multi-step behavioral sequence.

目标导向行为由几个顺序执行的运动步骤组成，这些运动步骤可能涉及眼睛、头部和伸手运动。目标导向的行为序列由外部感官刺激触发。序列的后续元素及其成功完成取决于步骤之间的感觉反馈，对运动命令的内部监控，以及内部状态变量，如注意力，期望和动机。在多步骤序列中，中脑顶盖和脑干核中不同类型的神经元表现出与感觉刺激的特征相关的放电模式，或者与运动模式的规划、选择和执行相关的放电模式。我们计划调查未解决的问题，这些不同的神经元合奏控制多步序列的视觉运动系统的斑马鱼（Danio rerio）的幼虫。由于它的小尺寸，透明的皮肤和遗传可塑性，这种脊椎动物模型提供了独特的机会，形象的分布式网络的神经动力学与目标导向的视觉引导行为在完整的动物。具体来说，我们计划测试多步行为序列是否由一组离散的运动模式组成。我们还将测试是否存在特定的时空分布的活动在视顶盖和网状脊髓系统编码的多步骤序列的各个步骤。最后，我们将解决的问题，如何动态的神经活动和短期的可塑性影响的耦合之间的个别运动步骤的多步行为序列的效率的决定因素。