Understanding of Molecular Phenomena on Planar and Nanosized GaP Surfaces Under Different Environmental Conditions

了解不同环境条件下平面和纳米级 GaP 表面的分子现象

• 批准号: 1052809
• 负责人: Albena Ivanisevic
• 金额: $ 42.34万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1052809&HistoricalAwards=false
• 关键词: Understanding; Molecular; Phenomena; Planar; Nanosized

The Environmental Chemical Sciences (ECS) program of the Division of Chemistry will support the research program of Prof. Albena Ivanisevic of Purdue University. Prof. Ivanisevic and her students will develop novel surface functionalization methods to form peptide coatings that passivate GaP surfaces in order to prevent the release of toxic Ga in biological systems, test the long term stability of peptide-coated GaP films, nanoparticles and nanowires in physiologically relevant conditions, and understand the molecular phenomena that govern their survival or deterioration under different environmental conditions. The specific aims of the study are: i) Explore surface functionalization schemes that result in the immobilization of peptides on GaP with high coverage and reproducibility while preventing the reformation of oxide on the semiconductor surface; ii) Quantify the amount of inorganic material released under different environmental conditions and use analytical tools to understand the processes associated with surface degradation; iii) Correlate stability under different environmental conditions with bio-recognition properties using Quartz Crystal Microbalance with Dissipation (QCM-D) and clinically relevant samples.Effective passivation of GaP surafces by peptide coatings will enable the application of GaP materials in biosensing platforms used in biological systems. It will also alleviate toxicity concerns associated with the wide spread use of GaP and other III-V semiconductor materials in the electronics industry. The project will provide excellent educational opportunities for students, including some from under represented groups, desiring to work at the interdiciplinary research area of nanomaterials toxicity.

化学系的环境化学科学（ECS）计划将支持普渡大学Albena Ivanisevic教授的研究计划。Ivanisevic教授和她的学生将开发新的表面功能化方法，以形成钝化GaP表面的肽涂层，以防止生物系统中有毒Ga的释放，测试肽涂层GaP薄膜，纳米颗粒和纳米线在生理相关条件下的长期稳定性，并了解在不同环境条件下管理其生存或恶化的分子现象。该研究的具体目的是：i）探索表面功能化方案，该方案导致肽在GaP上的固定化，具有高覆盖率和可重复性，同时防止半导体表面上氧化物的重新形成; ii）量化在不同环境条件下释放的无机材料的量，并使用分析工具来理解与表面降解相关的过程; iii）使用具有耗散的石英晶体微天平（QCM-D）和临床相关样品将不同环境条件下的稳定性与生物识别特性相关联。通过肽涂层对GaP表面的有效钝化将使GaP材料能够应用于生物系统中使用的生物传感平台。它还将缓解与GaP和其他III-V族半导体材料在电子工业中的广泛使用相关的毒性问题。该项目将为学生提供极好的教育机会，包括一些来自代表性不足的群体，希望在纳米材料毒性的跨学科研究领域工作。