Fabrication and Characterization of Surfaces Composed of Lithographically Defined Peptide Structures

由光刻定义的肽结构组成的表面的制造和表征

• 批准号: 0614132
• 负责人: Albena Ivanisevic
• 金额: $ 40.4万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0614132&HistoricalAwards=false
• 关键词: Fabrication; Characterization; Surfaces; Composed; Lithographically

The Analytical and Surface Chemistry (ASC) program of the Division of Chemistry will support the research program of Prof. Albena Ivanisevic of Purdue University. Prof. Ivanisevic research program focuses on the development of microfabricated patterned devices with biosensing capabilities. Prof. Ivanisevic and her students will develop surface chemistry strategies to immobilize unique peptides to the surface of semiconductor materials. The work will involve using unconventional lithographic approaches to precisely place the peptides on the surface of the semiconductor materials and a variety of surface spectroscopic techniques to understand the chemical composition, molecular conformation and mechanical properties of peptide features on the patterned surface. The fundamental knowledge gained will be later used to fabricate much improved microfabricated sensors for diagnostic purposes and improved platform for tissue engineering applications. The research of Prof. Ivanisevic will integrate measurement science with problems that are currently at the frontier of biological research and will serve as an ideal platform for inter-disciplinary education. It will provide an excellent educational opportunity for trainees desiring work at the interface of chemistry, material science and biology.

化学系的分析和表面化学(ASC)计划将支持普渡大学Albena Ivanisevic教授的研究计划。Ivanisevic教授的研究项目专注于开发具有生物传感能力的微制造图案化设备。Ivanisevic教授和她的学生将开发表面化学策略，将独特的多肽固定到半导体材料的表面。这项工作将涉及使用非传统的光刻方法将多肽精确地放置在半导体材料的表面，以及各种表面光谱技术来了解多肽在图案化表面上的化学组成、分子构象和机械性能。所获得的基础知识稍后将用于制造更多用于诊断目的的微细制造传感器和用于组织工程应用的改进平台。伊万尼舍维奇教授的研究将把测量科学与目前生物学研究前沿的问题结合起来，并将成为跨学科教育的理想平台。它将为希望在化学、材料科学和生物领域工作的学员提供一个极好的教育机会。