Mechanisms of Thiols and Thiocarbamides Activities in the Physiological Environment
Mechanisms of Thiols and Thiocarbamides Activities in the Physiological Environment
批准号:
1053611
负责人:
Reuben Simoyi
金额:
$31.5万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-15 至 2016-08-31
中文摘要
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英文摘要
The Chemical Catalysis Program in the Chemistry Division at the National Science Foundation supports Professor Reuben Simoyi of Portland State University for investigation of mechanisms and metabolite chemistry of novel organsulfur compounds as related to drug development. The goal of this work is to synthesize several series of drug-related thiourea derivatives, along with other organosulfur compounds, and evaluate both their metabolic activations and the reactivity of the resulting metabolites. Many new drugs contain organosulfur moieties and this work will help establish a deeper mechanistic understanding and quantify systematic protocols to assess their physiological response. Broader impacts of this research include its true interdisciplinary nature, blending synthesis with analytical methods to study an important class of biologically active molecules. Professor Simoyi has an outstanding track record with undergraduate researchers and in the training of scientists from underrepresented groups in his laboratory. This work will have a translational impact on the pharmaceutical industry by facilitating successful predictions of active compounds as potential drugs.
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会议论文
Kinetics and Mechanisms: Oxidation of Some Selected sulfur Compounds of Physiological and Environmental Importance
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批准号:0614924
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项目类别:Standard Grant
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资助金额:$30.2万
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财政年份:2006
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负责人:Reuben Simoyi
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依托单位:
South Africa Cooperative Research: Oxidation Mechanisms, Effect of pH and Probing of Possible Metal Ion Catalysis in the Reactions of Organosulfur Compounds
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批准号:0422689
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项目类别:Standard Grant
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资助金额:$0.0万
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财政年份:2004
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负责人:Reuben Simoyi
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依托单位:
US- Nigeria Planning Visit: Synthesis and Characterization of Some Reactive Sulfur-Containing Intermediates
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批准号:0341152
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项目类别:Standard Grant
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资助金额:$1.6万
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财政年份:2003
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负责人:Reuben Simoyi
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依托单位:
Kinetics and Mechanisms: Oxidation of Some Selected Sulfur Compounds of Physiological and Environmental Importance
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批准号:0341769
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项目类别:Standard Grant
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资助金额:$19.78万
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财政年份:2003
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负责人:Reuben Simoyi
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依托单位:
Kinetics and Mechanisms: Oxidation of Some Selected Sulfur Compounds of Physiological and Environmental Importance
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批准号:0137435
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项目类别:Standard Grant
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资助金额:$33.0万
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财政年份:2002
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负责人:Reuben Simoyi
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依托单位:
Kinetics and Mechanisms: Oxidation Mechanisms of Some Selected Sulfur Compounds
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批准号:9632592
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项目类别:Continuing Grant
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资助金额:$30.0万
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财政年份:1996
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负责人:Reuben Simoyi
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依托单位:
海外基金