Mechanisms of Thiols and Thiocarbamides Activities in the Physiological Environment

国家科学基金会化学部的化学催化计划支持波特兰州立大学的鲁本·西莫伊教授研究与药物开发相关的新型有机硫化合物的机理和代谢物化学。这项工作的目标是合成几个与药物相关的硫脲衍生物，以及其他有机硫化合物，并评估它们的代谢活性和所产生的代谢物的反应活性。许多新药含有有机硫部分，这项工作将有助于建立更深层次的机理理解，并量化系统的方案来评估它们的生理反应。这项研究的更广泛的影响包括它真正的跨学科性质，将合成与分析方法相结合来研究一类重要的生物活性分子。西莫伊教授在本科生研究人员以及在他的实验室培训来自代表性不足群体的科学家方面有着出色的记录。这项工作将通过促进活性化合物作为潜在药物的成功预测，对制药业产生翻译影响。

The Chemical Catalysis Program in the Chemistry Division at the National Science Foundation supports Professor Reuben Simoyi of Portland State University for investigation of mechanisms and metabolite chemistry of novel organsulfur compounds as related to drug development. The goal of this work is to synthesize several series of drug-related thiourea derivatives, along with other organosulfur compounds, and evaluate both their metabolic activations and the reactivity of the resulting metabolites. Many new drugs contain organosulfur moieties and this work will help establish a deeper mechanistic understanding and quantify systematic protocols to assess their physiological response. Broader impacts of this research include its true interdisciplinary nature, blending synthesis with analytical methods to study an important class of biologically active molecules. Professor Simoyi has an outstanding track record with undergraduate researchers and in the training of scientists from underrepresented groups in his laboratory. This work will have a translational impact on the pharmaceutical industry by facilitating successful predictions of active compounds as potential drugs.