US- Nigeria Planning Visit: Synthesis and Characterization of Some Reactive Sulfur-Containing Intermediates

美国-尼日利亚计划访问：一些活性含硫中间体的合成和表征

• 批准号: 0341152
• 负责人: Reuben Simoyi
• 金额: $ 1.6万
• 依托单位: Portland State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0341152&HistoricalAwards=false
• 关键词: US; Nigeria; Planning; Visit; Synthesis

In this planning grant, Dr. Simoyi will work with his Nigerian collaborator, Dr. Jonathan Ojo, to study sulfur-containing compounds and oxyhalogens that are very important species in chemistry, environmental and biological chemistry. Despite their importance, very little work has been done towards the elucidation of their basic chemistry and reaction mechanisms of these compounds. The oxidation of sulfur proceeds through many intermediate species, and the purpose of this international cooperative planning grant is to synthesize some of these postulated reactive intermediates to gain an insight into the complete oxidation mechanisms of these organosulfur compounds.Humans are exposed to organosulfur compounds everyday in the workplace (e.g, in paints and agrochemicals), and ingestion of these compounds can sometimes result in inadvertent toxicity (e.g. diisocyanates are ashtmatogens). These compounds are metabolically disposed of by the human body through oxidation; the resultant metabolites can be studied to assess the toxicities of the organosulfur. We postulate that these metabolites should be the series of sulfur oxo-acids that are formed as the sulfur center is successively oxidized to the sulfate, which is then eluted out of the physiological environment. The studies undertaken in this planning activity will help in framing research on predicting the toxicities of several previously uncharacterized organosulfur compounds. This award is co-funded by the Division of Chemistry.

Simoyi博士将与他的尼日利亚合作者Jonathan Ojo博士一起研究含硫化合物和氧卤化合物，这些化合物在化学，环境和生物化学中非常重要。尽管它们的重要性，很少的工作已经做了对这些化合物的基本化学和反应机理的阐明。硫的氧化是通过许多中间体进行的，这项国际合作计划资助的目的是合成这些假定的活性中间体，以深入了解这些有机硫化合物的完整氧化机制。（例如，在油漆和农用化学品中），并且这些化合物的摄入有时会导致意外的毒性（例如，二异氰酸酯是致灰剂）。这些化合物通过氧化被人体代谢处理;可以研究所得代谢物以评估有机硫的毒性。我们假设这些代谢物应该是一系列硫含氧酸，这些硫含氧酸是随着硫中心被连续氧化成硫酸盐而形成的，然后从生理环境中洗脱出来。在这项规划活动中进行的研究将有助于对预测几种以前没有特征的有机硫化合物的毒性进行研究。该奖项由化学部共同资助。