CAREER: Structural and Electronic Contributions to Reactivity in Peroxomanganese(III) Compounds

化学结构，动力学和机制计划支持堪萨斯大学的蒂莫西杰克逊教授的职业奖，他进行研究以了解锰（Mn）酶的机制，并改进催化各种反应的合成催化剂，包括人体活性氧的解毒，细菌和真菌中芳香族的降解，以及病原体中核苷酸向脱氧核苷酸的转化。过氧锰（III）（MnIII-O2）加合物已被提出作为这些生物和合成系统中的关键中间体。教授杰克逊将使用光谱和计算工具来定义的结构，电子，磁性和反应性能的过氧锰（III）中间体支持相关的生物和合成系统的配体。 这项工作将促进我们对锰酶的理解，并有助于锰氧化催化剂的发展。在美国国家科学基金会化学部化学结构、动力学和机制项目的支持下，蒂莫西杰克逊教授将进行研究，以更好地设计催化剂，并提高对酶的理解。这最终可以转化为改进的诊断和治疗药物。外展计划非常有创意，组织和计划非常好。拟议的外展活动将为100名中学女生、少数民族和经济困难背景的人提供机会，探索电磁辐射（光）如何影响他们的日常生活。为了整合研究和教育经验，研究生和本科生将担任营地导师。夏令营应该对处于中学生重要年龄的科学代表性不足的群体产生直接和积极的影响。建立一个难民营网站，提供教学录像，将广泛传播难民营材料。一些初步的研究数据已经在同行评审的期刊和专业会议上发表。

The Chemical Structure, Dynamics and Mechanisms Program supports the CAREER award of Professor Timothy Jackson at the University of Kansas who performs research to understand the mechanisms of Manganese (Mn) enzymes and improve synthetic catalysts that catalyze a diverse array of reactions including the detoxification of reactive oxygen species in humans, the degradation of aromatics in bacteria and fungi, and the conversion of nucleotides to deoxynucleotides in pathogens. Peroxomanganese(III) (MnIII-O2) adducts have been proposed as crucial intermediates in these biological and synthetic systems. Professor Jackson will use spectroscopic and computational tools to define the structural, electronic, magnetic, and reactivity properties of peroxomanganese (III) intermediates supported by ligands relevant to biological and synthetic systems. This work will advance our understanding of Mn enzymes and aid in the development of Mn oxidation catalysts.With the support of the Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation, Professor Timothy Jackson will perform research that can lead to better catalyst design and improved understanding of enzymes. This can ultimately translate into improved diagnostic and therapeutic medicinal agents. The outreach program is very creative and extremely well organized and planned. The proposed outreach activities will provide an opportunity for 100 middle school girls, minorities, and those from economically-disadvantaged backgrounds to explore how electromagnetic radiation (light) affects their daily lives. To integrate research and education experiences, graduate and undergraduate students will serve as camp mentors. The summer camps should have a direct and positive impact on underrepresented groups in science at the important age of middle school students. The development of a camp website with pedagogical videos will provide broad dissemination of camp materials. Some of the initial research data have already been presented in peer-reviewed journals and at professional meetings.