CAREER: Donor-acceptor-acceptor Homo-Nazarov cyclizations for facile access into functionalized six-membered ring systems

职业生涯：供体-受体-受体同系-纳扎罗夫环化，轻松进入功能化六元环系统

• 批准号: 1056687
• 负责人: Stefan France
• 金额: $ 55万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1056687&HistoricalAwards=false
• 关键词: CAREER; Donor; acceptor; Homo; Nazarov

With this CAREER award, the Chemical Synthesis program of the Division of Chemistry is supporting the research of Professor Stefan France of Georgia Institute of Technology. Professor France will develop methodology for the synthesis of six-membered carbocyclic and heterocyclic frameworks based on Lewis acid-catalyzed homo-Nazarov cyclizations of donor-acceptor-acceptor cyclopropanes. Specific aims include: 1) the use of novel donor-acceptor-acceptor cyclopropane substrates; 2) the use of other functionalizable acceptor groups; 3) the achievement of asymmetric induction through chirality transfer or asymmetric catalysis; 4) the exploitation of carbocation rearrangements as a synthetic tool; and 5) their applications toward the synthesis of complex molecules. Professor France will also initiate three educational projects that interweave research and teaching. The first project involves an outreach program at a local high school that promotes active learning through the design and implementation of the case study method in science. The second project involves redesigning the undergraduate introductory organic chemistry course in order to eliminate the traditional lecture model. The third project is focused on increasing the representation of underrepresented minorities in chemistry through a combination of recruiting efforts and mentoring activities. Besides these educational impacts, this work could lead to more efficient methods for the preparation of complex organic molecules. Therefore, it will have an impact on any area in which the synthesis of molecules is needed, such as the pharmaceutical, chemical, agricultural industry, and biological and chemical research activities.

有了这个职业奖，化学系的化学合成计划正在支持格鲁吉亚理工学院的斯特凡·法兰西教授的研究。 France教授将开发基于刘易斯酸催化的供体-受体-受体环丙烷的均Nazarov环化的六元碳环和杂环框架的合成方法。 具体目标包括：1）使用新的供体-受体-受体环丙烷底物; 2）使用其他可官能化的受体基团; 3）通过手性转移或不对称催化实现不对称诱导; 4）利用碳阳离子重排作为合成工具;和5）它们在合成复杂分子方面的应用。 法国教授还将启动三个教育项目，交织研究和教学。 第一个项目涉及在当地一所高中的推广计划，通过设计和实施科学案例研究方法促进主动学习。 第二个项目涉及重新设计本科有机化学导论课程，以消除传统的讲座模式。 第三个项目的重点是通过招聘工作和辅导活动相结合，增加在化学领域代表性不足的少数群体的代表性。 除了这些教育影响之外，这项工作还可以为复杂有机分子的制备带来更有效的方法。 因此，它将对任何需要合成分子的领域产生影响，例如制药，化学，农业以及生物和化学研究活动。