Mathematical modelling of the dynamics of multi-layered biological tissues

多层生物组织动力学的数学模型

• 批准号: DP160104342
• 负责人: Dr Zoltan Neufeld
• 金额: $ 26.04万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104342
• 关键词: Mathematical; modelling; dynamics; multi; layered

The project intends to develop a mathematical model of the basic mechanisms that determine the self-organisation of cells into complex tissues during the development of the embryo. Tissue function requires a non-trivial tissue architecture often composed of multiple cell layers which exhibit a remarkable capacity for renewal and defect correction. A cardinal part of embryonic development involves robust shaping of multi-layered tissue morphologies. The project plans to use mathematical models to determine how complex, three-dimensional structures arise from adaptive multicellular biomechanical interactions. It plans to develop a novel computational modelling framework to represent and analyse such systems, which may be applicable to a wide range of problems where tissue mechanics is a key factor such as bone remodelling and wound healing.

该项目旨在开发一种基本机制的数学模型，该机制决定了胚胎发育过程中细胞自我组织成复杂组织的过程。组织功能需要通常由多个细胞层组成的非平凡组织结构，其表现出显著的更新和缺陷校正能力。胚胎发育的主要部分涉及多层组织形态的稳健成形。该项目计划使用数学模型来确定自适应多细胞生物力学相互作用如何产生复杂的三维结构。它计划开发一种新的计算建模框架来表示和分析这样的系统，这可能适用于组织力学是一个关键因素，如骨重建和伤口愈合的广泛问题。