Mathematical modeling of multicellular organization of epithelial tissues

上皮组织多细胞组织的数学模型

• 批准号: FT130100659
• 负责人: Dr Zoltan Neufeld
• 金额: $ 50.63万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100659
• 关键词: Mathematical; modeling; multicellular; organization; epithelial

This project will use mathematical modelling and computer simulations to understand the dynamic organisation of epithelial tissues in close interaction with ongoing laboratory experiments. The key challenge is to develop a multi-scale modelling framework that is capable of bridging the gap between biochemical and biophysical sub-cellular processes, cell-cell interactions and the large scale multicellular properties of tissues composed of large cell populations. This will require the design of novel mathematical approximation techniques and application of high performance parallel computing technology specifically adapted for the description of multicellular systems.

该项目将使用数学模型和计算机模拟来了解上皮组织的动态组织，并与正在进行的实验室实验密切相关。关键的挑战是开发一个多尺度建模框架，能够弥合生化和生物物理亚细胞过程，细胞-细胞相互作用以及由大细胞群组成的组织的大规模多细胞特性之间的差距。这将需要设计新颖的数学近似技术和应用高性能并行计算技术，专门用于多细胞系统的描述。