REU Site: Modeling and Simulation in Systems Biology

REU 网站：系统生物学建模与仿真

• 批准号: 1062878
• 负责人: Sallie Keller
• 金额: $ 38.62万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1062878&HistoricalAwards=false
• 关键词: REU; Site; Modeling; Simulation; Systems

The objective of the proposed program is to provide a 10-week residential summer research experience in mathematical biology to undergraduate students from around the U.S. and Puerto Rico, with the goal of increasing their desire and preparation to enter a Ph.D. program in mathematics or computational biology. The students will be mentored by faculty from the Virginia Bioinformatics Institute (VBI) and the Wake Forest University School of Medicine in Winston-Salem, NC. They will participate in research projects in two related areas: Modeling of mammalian intracellular iron metabolism in two cell types, as well as a multiscale model connecting the intracellular and the systemic scales; and construction and implementation of mathematical algorithms for the analysis of biological networks. These algorithms will be used to study models of iron metabolism. It is widely recognized that mathematical tools are indispensable for the understanding of biological networks and their dynamic properties. The proposed program involves students in research projects that model biological networks with mathematical tools. The students will develop the tools as well as apply them. The projects are carried out in close collaboration with experimental scientists. The program will prepare a total of 36 undergraduates for the challenges of modern interdisciplinary quantitative life sciences research. It will motivate them to enter a Ph.D. program and will help them be successful in their graduate career. Particular emphasis in recruiting will be placed on the inclusion of members from underrepresented groups. Thus, the program will contribute to the recruitment and training of a highly specialized workforce at the interface of experiment and computation, responding to the ever-growing need for experts that can apply quantitative methods to life science and biomedical research.

拟议计划的目标是为来自美国和波多黎各的本科生提供为期10周的数学生物学夏季住宅研究经验，以增加他们进入博士学位的愿望和准备。数学或计算生物学的程序。这些学生将由弗吉尼亚生物信息学研究所（VBI）和北卡罗来纳州温斯顿-塞勒姆的维克森林大学医学院的教师指导。他们将参与两个相关领域的研究项目：两种细胞类型中哺乳动物细胞内铁代谢的建模，以及连接细胞内和系统尺度的多尺度模型;以及用于生物网络分析的数学算法的构建和实施。这些算法将用于研究铁代谢模型。数学工具对于理解生物网络及其动态特性是不可或缺的。拟议的计划涉及学生的研究项目，模型与数学工具的生物网络。学生将开发工具，以及应用它们。这些项目是与实验科学家密切合作进行的。该计划将为36名本科生准备现代跨学科定量生命科学研究的挑战。这将激励他们进入博士学位。计划，并将帮助他们在他们的研究生生涯取得成功。 征聘工作将特别强调吸收代表性不足群体的成员。因此，该计划将有助于在实验和计算的接口高度专业化的劳动力的招聘和培训，以满足对能够将定量方法应用于生命科学和生物医学研究的专家日益增长的需求。